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HomoloGene:68048. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ABCC8,  H.sapiens
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
NP_001274103.1
1582 aa
ABCC8,  P.troglodytes
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
XP_508310.4
1618 aa
ABCC8,  M.mulatta
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
XP_001088694.1
1581 aa
ABCC8,  C.lupus
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
XP_005633781.1
1499 aa
ABCC8,  B.taurus
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
NP_001192539.1
1581 aa
Abcc8,  M.musculus
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
NP_035640.2
1588 aa
Abcc8,  R.norvegicus
ATP-binding cassette, subfamily C (CFTR/MRP), member 8
NP_037171.2
1582 aa
ABCC8,  G.gallus
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
XP_421005.2
1595 aa
abcc8,  D.rerio
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
NP_001166118.2
1581 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, noninsulin-dependent.
Hypoglycemia of infancy, leucine-sensitive.
Hyperinsulinemic hypoglycemia, familial, 1.
Diabetes mellitus, permanent neonatal.
Diabetes mellitus, transient neonatal 2.



Publications
Articles associated with genes and sequences of this homology group.

Sulfonylurea receptor 1 expression in human cerebral infarcts.
Mehta RI, et al. J Neuropathol Exp Neurol 72, 871-83 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P-loop_NTPase (cl09099)
  P-loop containing Nucleoside Triphosphate Hydrolases.
ABC_membrane (pfam00664)
  ABC transporter transmembrane region.
CydD (COG4988)
  ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].
ABC_membrane_2 (cl00549)
  ABC transporter transmembrane region 2.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
ABC_membrane (pfam00664)
  ABC transporter transmembrane region.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Abcc8 includes H.sapiens ABCC8 and R.norvegicus Abcc8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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