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HomoloGene:30994. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HMGCR,  H.sapiens
3-hydroxy-3-methylglutaryl-CoA reductase
NP_000850.1
888 aa
HMGCR,  P.troglodytes
3-hydroxy-3-methylglutaryl-CoA reductase
XP_001148405.2
908 aa
HMGCR,  M.mulatta
3-hydroxy-3-methylglutaryl-CoA reductase
XP_002804463.1
908 aa
HMGCR,  C.lupus
3-hydroxy-3-methylglutaryl-CoA reductase
XP_536323.3
904 aa
HMGCR,  B.taurus
3-hydroxy-3-methylglutaryl-CoA reductase
NP_001099083.1
888 aa
Hmgcr,  M.musculus
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
NP_032281.2
887 aa
Hmgcr,  R.norvegicus
3-hydroxy-3-methylglutaryl-CoA reductase
NP_037266.2
887 aa
HMGCR,  G.gallus
3-hydroxy-3-methylglutaryl-CoA reductase
NP_989816.1
875 aa
hmgcr,  X.tropicalis
3-hydroxy-3-methylglutaryl-CoA reductase
XP_004910453.1
883 aa
hmgcra,  D.rerio
3-hydroxy-3-methylglutaryl-Coenzyme A reductase a
NP_001073446.1
884 aa
Hmgcr,  D.melanogaster
HMG Coenzyme A reductase
NP_732900.1
920 aa
AgaP_AGAP002288,  A.gambiae
AgaP_AGAP002288
XP_307890.5
895 aa
hmgr-1,  C.elegans
hmgr-1
NP_498626.2
550 aa
HMG1,  S.cerevisiae
HMG1
NP_013636.1
1054 aa
HMG2,  S.cerevisiae
HMG2
NP_013555.1
1045 aa
KLLA0B04642g,  K.lactis
KLLA0B04642g
XP_451740.1
1072 aa
AGOS_AER152W,  E.gossypii
AGOS_AER152W
NP_985010.2
1028 aa
hmg1,  S.pombe
hmg1
NP_588235.1
1053 aa
MGG_08975,  M.oryzae
MGG_08975
XP_003714014.1
1201 aa
NCU00712,  N.crassa
NCU00712
XP_964546.1
1173 aa
HMG1,  A.thaliana
HMG1
NP_177775.2
642 aa
HMG2,  A.thaliana
HMG2
NP_179329.1
562 aa
Os09g0492700,  O.sativa
Os09g0492700
NP_001063541.1
576 aa
Os08g0512700,  O.sativa
Os08g0512700
NP_001062221.1
419 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Statins, attenuated cholesterol lowering by.



Publications
Articles associated with genes and sequences of this homology group.

Regulation of HMG-CoA reductase in mammals and yeast.
Burg JS & Espenshade PJ. Prog Lipid Res 50, 403-10 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
SecD_SecF (cl14618)
  Protein export membrane protein.
Sterol-sensing (pfam12349)
  Sterol-sensing domain of SREBP cleavage-activation.
HPIH (pfam13323)
  N-terminal domain with HPIH motif.
HMG-CoA_reductase (cl00205)
  Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR) is a tightly regulated enzyme, which catalyzes the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. In mammals, this is the rate limiting committed step in cholesterol biosynthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. There are two classes of HMGR: class I enzymes which are found predominantly in eukaryotes and contain N-terminal membrane regions and class II enzymes which are found primarily in prokaryotes and are soluble as they lack the membrane region. With the exception of Archaeoglobus fulgidus, most archeae are assigned to class I, based on sequence similarity of the active site, even though they lack membrane regions. Yeast and human HMGR are divergent in their N-terminal regions, but are conserved in their active site. In contrast, human and bacterial HMGR differ in their active site architecture. While the prokaryotic enzyme is a homodimer, the eukaryotic enzyme is a homotetramer.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hmgcr includes H.sapiens HMGCR and R.norvegicus Hmgcr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (102 transcripts, 33 species)
Liliopsida - monocots (23 transcripts, 8 species)
Coniferopsida - conifers (13 transcripts, 3 species)
Bryopsida - mosses (3 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Actinopterygii - bony fishes (17 transcripts, 11 species)
Mammalia - mammals (16 transcripts, 15 species)
Amphibia - amphibians (4 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (6 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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