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HomoloGene:2616. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CDC45,  H.sapiens
cell division cycle 45
NP_001171481.1
598 aa
CDC45,  P.troglodytes
cell division cycle 45 homolog (S. cerevisiae)
XP_003317140.1
598 aa
CDC45,  M.mulatta
cell division cycle 45 homolog (S. cerevisiae)
XP_001104872.2
598 aa
CDC45,  C.lupus
cell division cycle 45
XP_543547.3
569 aa
CDC45,  B.taurus
cell division cycle 45 homolog (S. cerevisiae)
NP_001019661.1
616 aa
Cdc45,  M.musculus
cell division cycle 45
NP_033992.2
566 aa
Cdc45,  R.norvegicus
cell division cycle 45
NP_001099336.1
570 aa
CDC45,  G.gallus
cell division cycle 45 homolog (S. cerevisiae)
XP_415070.2
566 aa
cdc45,  X.tropicalis
cell division cycle 45
XP_004910630.1
569 aa
cdc45,  D.rerio
CDC45 cell division cycle 45 homolog (S. cerevisiae)
NP_998551.1
572 aa
CDC45L,  D.melanogaster
CDC45L
NP_569880.1
575 aa
AgaP_AGAP011961,  A.gambiae
AgaP_AGAP011961
XP_320573.1
574 aa
F34D10.2,  C.elegans
F34D10.2
NP_497756.2
574 aa
CDC45,  S.cerevisiae
CDC45
NP_013204.1
650 aa
KLLA0F19822g,  K.lactis
KLLA0F19822g
XP_455970.1
664 aa
AGOS_AGR071C,  E.gossypii
AGOS_AGR071C
NP_986736.1
612 aa
cdc45,  S.pombe
cdc45
NP_594693.1
638 aa
MGG_01549,  M.oryzae
MGG_01549
XP_003714523.1
871 aa
NCU04378,  N.crassa
NCU04378
XP_957455.1
874 aa
CDC45,  A.thaliana
CDC45
NP_189146.1
596 aa
Os11g0128400,  O.sativa
Os11g0128400
NP_001065635.1
604 aa
Os12g0124700,  O.sativa
Os12g0124700
NP_001066041.1
604 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Protein interaction and cellular localization of human CDC45.
Takaya J, et al. J Biochem 153, 381-8 (2013).
Cdc45 degradation during differentiation and apoptosis.
Pollok S & Grosse F. Biochem Biophys Res Commun 362, 910-5 (2007).
Human Cdc45 is a proliferation-associated antigen.
Pollok S, et al. FEBS J 274, 3669-84 (2007).
Emerging mechanisms of eukaryotic DNA replication initiation.
Leatherwood J. Curr Opin Cell Biol 10, 742-8 (1998).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CDC45 (pfam02724)
  CDC45-like protein.
CDC45 (pfam02724)
  CDC45-like protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdc45 includes H.sapiens CDC45.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 7 species)
Mammalia - mammals (9 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (11 transcripts, 9 species)
Liliopsida - monocots (6 transcripts, 5 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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