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HomoloGene:2486. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DNAJC3,  H.sapiens
DnaJ (Hsp40) homolog, subfamily C, member 3
NP_006251.1
504 aa
DNAJC3,  P.troglodytes
DnaJ (Hsp40) homolog, subfamily C, member 3
XP_001138934.1
504 aa
DNAJC3,  M.mulatta
DnaJ (Hsp40) homolog, subfamily C, member 3
XP_001086487.1
504 aa
DNAJC3,  C.lupus
DnaJ (Hsp40) homolog, subfamily C, member 3
XP_005634076.1
480 aa
DNAJC3,  B.taurus
DnaJ (Hsp40) homolog, subfamily C, member 3
NP_777181.1
504 aa
Dnajc3,  M.musculus
DnaJ (Hsp40) homolog, subfamily C, member 3
NP_032955.2
504 aa
Dnajc3,  R.norvegicus
DnaJ (Hsp40) homolog, subfamily C, member 3
NP_071568.1
504 aa
DNAJC3,  G.gallus
DnaJ (Hsp40) homolog, subfamily C, member 3
NP_001008437.1
503 aa
dnajc3,  X.tropicalis
DnaJ (Hsp40) homolog, subfamily C, member 3
NP_001011485.1
437 aa
dnajc3a,  D.rerio
DnaJ (Hsp40) homolog, subfamily C, member 3a
NP_955904.2
504 aa
P58IPK,  D.melanogaster
P58IPK
NP_649916.1
498 aa
AgaP_AGAP002752,  A.gambiae
AgaP_AGAP002752
XP_312173.2
495 aa
dnj-7,  C.elegans
dnj-7
NP_509209.1
491 aa
dnj-28,  C.elegans
dnj-28
NP_491084.1
494 aa
MGG_03565,  M.oryzae
MGG_03565
XP_003716351.1
529 aa
NCU02424,  N.crassa
NCU02424
XP_959606.1
517 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The crystal structure of the human co-chaperone P58(IPK).
Svärd M, et al. PLoS One 6, e22337 (2011).
Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment.
Tao J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 108-10 (2008).
The role of p58IPK in protecting the stressed endoplasmic reticulum.
Rutkowski DT, et al. Mol Biol Cell 18, 3681-91 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DnaJ (COG0484)
  DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones].
TPR (cd00189)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR (cl02429)
  Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
TPR_11 (pfam13414)
  TPR repeat.
DnaJ (cl02542)
  DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dnajc3 includes H.sapiens DNAJC3 and R.norvegicus Dnajc3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 14 species)
Actinopterygii - bony fishes (15 transcripts, 11 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 11 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)
Liliopsida - monocots (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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