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HomoloGene:56577. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CAMK2A,  H.sapiens
calcium/calmodulin-dependent protein kinase II alpha
NP_057065.2
489 aa
CAMK2A,  P.troglodytes
calcium/calmodulin-dependent protein kinase II alpha
XP_001165329.2
470 aa
CAMK2A,  C.lupus
calcium/calmodulin-dependent protein kinase II alpha
XP_005619357.1
489 aa
CAMK2A,  B.taurus
calcium/calmodulin-dependent protein kinase II alpha
NP_001069406.1
478 aa
Camk2a,  M.musculus
calcium/calmodulin-dependent protein kinase II alpha
NP_803126.1
478 aa
Camk2a,  R.norvegicus
calcium/calmodulin-dependent protein kinase II alpha
NP_037052.1
478 aa
CAMK2A,  G.gallus
calcium/calmodulin-dependent protein kinase II alpha
NP_989626.1
489 aa
camk2a,  X.tropicalis
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
NP_001093737.1
489 aa
camk2a,  D.rerio
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
NP_001017741.2
478 aa
Os12g0133500,  O.sativa
Os12g0133500
NP_001176777.1
572 aa
Os11g0136600,  O.sativa
Os11g0136600
NP_001065691.1
541 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

CaMKII is essential for the proasthmatic effects of oxidation.
Sanders PN, et al. Sci Transl Med 5, 195ra97 (2013).
αCaMKII autophosphorylation controls the establishment of alcohol drinking behavior.
Easton AC, et al. Neuropsychopharmacology 38, 1636-47 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CaMKII_AD (pfam08332)
  Calcium/calmodulin dependent protein kinase II Association.
PTZ00184 (PTZ00184)
  calmodulin; Provisional.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
CaMKII_AD (cl17504)
  Calcium/calmodulin dependent protein kinase II Association.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Camk2a includes H.sapiens CAMK2A and R.norvegicus Camk2a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (43 transcripts, 21 species)
Liliopsida - monocots (12 transcripts, 7 species)
Bryopsida - mosses (4 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Actinopterygii - bony fishes (15 transcripts, 10 species)
Mammalia - mammals (13 transcripts, 12 species)
Aves - birds (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)
Trematoda - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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