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HomoloGene:69013. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

MARK2,  H.sapiens
MAP/microtubule affinity-regulating kinase 2
788 aa
MARK2,  P.troglodytes
MAP/microtubule affinity-regulating kinase 2
450 aa
MARK2,  M.mulatta
MAP/microtubule affinity-regulating kinase 2
778 aa
MARK2,  C.lupus
MAP/microtubule affinity-regulating kinase 2
806 aa
MARK2,  B.taurus
MAP/microtubule affinity-regulating kinase 2
691 aa
Mark2,  M.musculus
MAP/microtubule affinity-regulating kinase 2
776 aa
Mark2,  R.norvegicus
MAP/microtubule affinity-regulating kinase 2
722 aa
mark2,  X.tropicalis
MAP/microtubule affinity-regulating kinase 2
783 aa
mark2b,  D.rerio
MAP/microtubule affinity-regulating kinase 2b
802 aa
mark2a,  D.rerio
MAP/microtubule affinity-regulating kinase 2a
759 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

MARK2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulb.
Mejia-Gervacio S, et al. Mol Cell Neurosci 49, 97-103 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
Rer1 (cl02175)
  Rer1 family.
APC_basic (pfam05956)
  APC basic domain.
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
AMPKA_C_like (cl17070)
  C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mark2 includes H.sapiens MARK2 and R.norvegicus Mark2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)

Insecta - insects (2 transcripts, 2 species)

Eudicotyledons - eudicots (1 transcript, 1 species)

Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Monosiga - choanoflagellates (1 transcript, 1 species)




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