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HomoloGene:55912. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LMNB1,  H.sapiens
lamin B1
NP_005564.1
586 aa
LMNB1,  P.troglodytes
lamin B1
XP_001158070.2
586 aa
LMNB1,  M.mulatta
lamin B1
XP_001097340.1
586 aa
LMNB1,  C.lupus
lamin B1
XP_531892.3
454 aa
LMNB1,  B.taurus
lamin B1
NP_001096765.1
586 aa
Lmnb1,  M.musculus
lamin B1
NP_034851.2
588 aa
Lmnb1,  R.norvegicus
lamin B1
NP_446357.1
587 aa
LMNB1,  G.gallus
lamin B1
NP_990617.1
584 aa
lmnb1,  X.tropicalis
lamin B1
NP_989198.1
584 aa
lmnb1,  D.rerio
lamin B1
NP_694504.2
588 aa
lmn-1,  C.elegans
lmn-1
NP_492371.1
566 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukodystrophy, adult-onset, autosomal dominant.



Publications
Articles associated with genes and sequences of this homology group.

Is LMNB1 a susceptibility gene for neural tube defects in humans?
Robinson A, et al. Birth Defects Res A Clin Mol Teratol 97, 398-402 (2013).
The role of nuclear lamin B1 in cell proliferation and senescence.
Shimi T, et al. Genes Dev 25, 2579-93 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Filament (pfam00038)
  Intermediate filament protein.
LTD (pfam00932)
  Lamin Tail Domain.
LTD (pfam00932)
  Lamin Tail Domain.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lmnb1 includes H.sapiens LMNB1 and R.norvegicus Lmnb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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