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HomoloGene:30964. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NCF1,  H.sapiens
neutrophil cytosolic factor 1
NP_000256.4
390 aa
NCF1,  P.troglodytes
neutrophil cytosolic factor 1
XP_001152639.1
390 aa
NCF1,  M.mulatta
neutrophil cytosolic factor 1
XP_001084055.1
390 aa
NCF1,  C.lupus
neutrophil cytosolic factor 1
XP_849574.2
391 aa
NCF1,  B.taurus
neutrophil cytosolic factor 1
NP_776544.1
392 aa
Ncf1,  M.musculus
neutrophil cytosolic factor 1
NP_001272966.1
404 aa
Ncf1,  R.norvegicus
neutrophil cytosolic factor 1
NP_446186.2
389 aa
NCF1,  G.gallus
neutrophil cytosolic factor 1
NP_001025880.1
388 aa
ncf1,  X.tropicalis
neutrophil cytosolic factor 1
NP_001106375.1
391 aa
ncf1,  D.rerio
neutrophil cytosolic factor 1
NP_001025242.1
410 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Chronic granulomatous disease due to deficiency of NCF-1.



Publications
Articles associated with genes and sequences of this homology group.

Defining p47-phox deficient Chronic Granulomatous Disease in a Malay family.
Gill HK, et al. Asian Pac J Allergy Immunol 30, 313-20 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
p47_phox_C (pfam08944)
  NADPH oxidase subunit p47Phox, C terminal domain.
PX_domain (cl02563)
  The Phox Homology domain, a phosphoinositide binding module.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ncf1 includes H.sapiens NCF1C and R.norvegicus Ncf1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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