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HomoloGene:8293. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DROSHA,  H.sapiens
drosha, ribonuclease type III
NP_037367.3
1374 aa
DROSHA,  P.troglodytes
drosha, ribonuclease type III
XP_001157472.2
1374 aa
DROSHA,  M.mulatta
drosha, ribonuclease type III
XP_002804372.1
1374 aa
DROSHA,  C.lupus
drosha, ribonuclease type III
XP_854135.2
1373 aa
DROSHA,  B.taurus
drosha, ribonuclease type III
XP_005221686.1
1375 aa
Drosha,  M.musculus
drosha, ribonuclease type III
NP_001123621.1
1373 aa
Drosha,  R.norvegicus
drosha, ribonuclease type III
NP_001101125.2
1373 aa
DROSHA,  G.gallus
drosha, ribonuclease type III
NP_001006379.1
1336 aa
drosha,  X.tropicalis
drosha, ribonuclease type III
NP_001107152.1
1325 aa
rnasen,  D.rerio
ribonuclease type III, nuclear
NP_001103942.1
1289 aa
drosha,  D.melanogaster
drosha
NP_477436.1
1327 aa
AgaP_AGAP008087,  A.gambiae
AgaP_AGAP008087
XP_555381.3
1404 aa
drsh-1,  C.elegans
drsh-1
NP_492599.1
1086 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The Microprocessor controls the activity of mammalian retrotransposons.
Heras SR, et al. Nat Struct Mol Biol 20, 1173-81 (2013).
Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.
Oskowitz AZ, et al. Int J Biochem Cell Biol 43, 1563-72 (2011).
Expanding the role of Drosha to the regulation of viral gene expression.
Lin YT & Sullivan CS. Proc Natl Acad Sci U S A 108, 11229-34 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Extensin_2 (pfam04554)
  Extensin-like region.
Transformer (pfam06495)
  Fruit fly transformer protein.
DUF1777 (pfam08648)
  Protein of unknown function (DUF1777).
DLL_N (pfam12413)
  Homeobox protein distal-less-like N terminal.
PRP38_assoc (pfam12871)
  Pre-mRNA-splicing factor 38-associated hydrophilic C-term.
DSRM (cl00054)
  Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
RIBOc (cl00258)
  RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Drosha includes H.sapiens DROSHA.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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