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HomoloGene:473. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

IL5RA,  H.sapiens
interleukin 5 receptor, alpha
420 aa
IL5RA,  P.troglodytes
interleukin 5 receptor, alpha
420 aa
IL5RA,  C.lupus
interleukin 5 receptor, alpha
417 aa
IL5RA,  B.taurus
interleukin 5 receptor, alpha
432 aa
Il5ra,  M.musculus
interleukin 5 receptor, alpha
415 aa
Il5ra,  R.norvegicus
interleukin 5 receptor, alpha
414 aa
IL5RA,  G.gallus
interleukin 5 receptor, alpha
424 aa
il5ra,  X.tropicalis
interleukin 5 receptor, alpha
433 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis.
Wilson TM, et al. J Allergy Clin Immunol 128, 1086-92.e1-3 (2011).
Separate endocytic pathways regulate IL-5 receptor internalization and signaling.
Lei JT & Martinez-Moczygemba M. J Leukoc Biol 84, 499-509 (2008).
JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.
Martinez-Moczygemba M, et al. J Leukoc Biol 81, 1137-48 (2007).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tissue_fac (pfam01108)
  Tissue factor.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il5ra includes H.sapiens IL5RA and R.norvegicus Il5ra.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (4 transcripts, 4 species)




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