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HomoloGene:41568. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NOX5,  H.sapiens
NADPH oxidase, EF-hand calcium binding domain 5
NP_001171708.1
737 aa
NOX5,  P.troglodytes
NADPH oxidase, EF-hand calcium binding domain 5
XP_003952732.1
737 aa
NOX5,  M.mulatta
NADPH oxidase, EF-hand calcium binding domain 5
XP_001085148.2
674 aa
NOX5,  C.lupus
NADPH oxidase, EF-hand calcium binding domain 5
NP_001096688.1
745 aa
NOX5,  B.taurus
NADPH oxidase, EF-hand calcium binding domain 5
NP_001094607.1
755 aa
NOX5,  G.gallus
NADPH oxidase, EF-hand calcium binding domain 5
NP_001093755.1
749 aa
nox5,  X.tropicalis
NADPH oxidase, EF-hand calcium binding domain 5
XP_002933005.2
774 aa
nox5,  D.rerio
NADPH oxidase, EF-hand calcium binding domain 5
XP_001921894.1
718 aa
Nox,  D.melanogaster
NADPH oxidase
NP_001097336.1
1340 aa
AgaP_AGAP008072,  A.gambiae
AgaP_AGAP008072
XP_317385.4
1053 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

NOX5 in human spermatozoa: expression, function, and regulation.
Musset B, et al. J Biol Chem 287, 9376-88 (2012).
NOX5: from basic biology to signaling and disease.
Bedard K, et al. Free Radic Biol Med 52, 725-34 (2012).
Molecular regulation of NADPH oxidase 5 via the MAPK pathway.
Pandey D & Fulton DJ. Am J Physiol Heart Circ Physiol 300, H1336-44 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NAD_binding_6 (pfam08030)
  Ferric reductase NAD binding domain.
Ferric_reduct (pfam01794)
  Ferric reductase like transmembrane component.
EF_hand_5 (pfam13499)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
Ferric_reduct (cl01043)
  This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

 

 

 

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