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HomoloGene:37680. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PSAP,  H.sapiens
prosaposin
NP_001035931.1
526 aa
PSAP,  P.troglodytes
prosaposin
XP_507840.2
527 aa
PSAP,  M.mulatta
prosaposin
XP_001107102.1
527 aa
PSAP,  C.lupus
prosaposin
XP_005619049.1
526 aa
PSAP,  B.taurus
prosaposin
NP_776586.1
525 aa
Psap,  M.musculus
prosaposin
NP_001139593.1
556 aa
Psap,  R.norvegicus
prosaposin
NP_001177166.1
556 aa
PSAP,  G.gallus
prosaposin
NP_990142.1
518 aa
psap,  X.tropicalis
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
NP_001017285.1
438 aa
psap,  D.rerio
prosaposin
NP_571958.1
522 aa
Sap-r,  D.melanogaster
Saposin-related
NP_524597.1
953 aa
AgaP_AGAP001082,  A.gambiae
AgaP_AGAP001082
XP_003437209.1
1007 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Combined SAP deficiency.
Metachromatic leukodystrophy due to deficiency of SAP-1.
Gaucher disease, atypical.



Publications
Articles associated with genes and sequences of this homology group.

Distribution of prosaposin in rat lymphatic tissues.
Shimokawa T, et al. Cell Tissue Res 352, 685-93 (2013).
Chronological changes in prosaposin in the developing rat brain.
Xue B, et al. Neurosci Res 71, 22-34 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SapB_2 (pfam03489)
  Saposin-like type B, region 2.
SapB_1 (pfam05184)
  Saposin-like type B, region 1.
SapA (cl02494)
  Saposin A-type domain.
SapB (smart00741)
  Saposin (B) Domains.
SapB_2 (pfam03489)
  Saposin-like type B, region 2.
SapB_1 (pfam05184)
  Saposin-like type B, region 1.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Psap includes H.sapiens PSAP and R.norvegicus Psap.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 17 species)
Actinopterygii - bony fishes (14 transcripts, 10 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 9 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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