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HomoloGene:48235. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SLC25A12,  H.sapiens
solute carrier family 25 (aspartate/glutamate carrier), member 12
NP_003696.2
678 aa
SLC25A12,  P.troglodytes
solute carrier family 25 (aspartate/glutamate carrier), member 12
XP_003949966.1
770 aa
SLC25A12,  M.mulatta
solute carrier family 25 (aspartate/glutamate carrier), member 12
XP_001085208.1
678 aa
SLC25A12,  C.lupus
solute carrier family 25 (aspartate/glutamate carrier), member 12
XP_005640369.1
680 aa
SLC25A12,  B.taurus
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
NP_001094664.1
675 aa
Slc25a12,  M.musculus
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
NP_766024.1
677 aa
SLC25A12,  G.gallus
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
XP_428938.4
682 aa
slc25a12,  D.rerio
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
NP_997947.1
682 aa
aralar1,  D.melanogaster
aralar1
NP_001247368.1
707 aa
AgaP_AGAP000958,  A.gambiae
AgaP_AGAP000958
XP_309148.5
668 aa
K02F3.2,  C.elegans
K02F3.2
NP_497274.2
707 aa
MGG_07066,  M.oryzae
MGG_07066
XP_003715248.1
710 aa
NCU01241,  N.crassa
NCU01241
XP_961607.1
706 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypomyelination, global cerebral.



Publications
Articles associated with genes and sequences of this homology group.

Cytosolic reducing power preserves glutamate in retina.
Du J, et al. Proc Natl Acad Sci U S A 110, 18501-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Mito_carr (pfam00153)
  Mitochondrial carrier protein.
EF_hand_5 (pfam13499)
  EF-hand domain pair.
EF_hand_6 (pfam13833)
  EF-hand domain pair.
FRQ1 (COG5126)
  Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only].
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
S-100 (cl08302)
  S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
Mito_carr (pfam00153)
  Mitochondrial carrier protein.
EF-hand_7 (pfam13499)
  EF-hand domain pair.
EF-hand_8 (cl17302)
  EF-hand domain pair.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc25a12 includes H.sapiens SLC25A12.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 10 species)
Mammalia - mammals (19 transcripts, 13 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 12 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

 

 

 

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