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HomoloGene:3645. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IDE,  H.sapiens
insulin-degrading enzyme
NP_004960.2
1019 aa
IDE,  P.troglodytes
insulin-degrading enzyme
XP_507922.2
1019 aa
IDE,  M.mulatta
insulin-degrading enzyme
XP_001090249.1
1019 aa
IDE,  C.lupus
insulin-degrading enzyme
XP_534963.3
1025 aa
IDE,  B.taurus
insulin-degrading enzyme
NP_001069317.1
1019 aa
Ide,  M.musculus
insulin degrading enzyme
NP_112419.3
1019 aa
Ide,  R.norvegicus
insulin degrading enzyme
NP_037291.1
1019 aa
IDE,  G.gallus
insulin-degrading enzyme
XP_421686.4
1021 aa
ide,  X.tropicalis
insulin-degrading enzyme
XP_002939138.2
1011 aa
ide,  D.rerio
insulin-degrading enzyme
NP_001082994.1
978 aa
Ide,  D.melanogaster
Insulin degrading metalloproteinase
NP_524182.3
990 aa
AgaP_AGAP010351,  A.gambiae
AgaP_AGAP010351
XP_311589.4
1030 aa
CELE_Y70C5C.1,  C.elegans
CELE_Y70C5C.1
NP_507226.2
985 aa
C28F5.4,  C.elegans
C28F5.4
NP_495575.2
856 aa
F44E7.4,  C.elegans
F44E7.4
NP_741542.1
1051 aa
C02G6.2,  C.elegans
C02G6.2
NP_504531.2
816 aa
C02G6.1,  C.elegans
C02G6.1
NP_504532.1
980 aa
STE23,  S.cerevisiae
STE23
NP_013493.2
1027 aa
KLLA0E05105g,  K.lactis
KLLA0E05105g
XP_454175.1
1004 aa
AGOS_AER053C,  E.gossypii
AGOS_AER053C
NP_984913.2
1013 aa
mug138,  S.pombe
mug138
NP_593966.1
969 aa
MGG_13149,  M.oryzae
MGG_13149
XP_003710564.1
1126 aa
NCU00481,  N.crassa
NCU00481
XP_956166.1
1082 aa
AT2G41790,  A.thaliana
AT2G41790
NP_181710.1
970 aa
AT3G57470,  A.thaliana
AT3G57470
NP_001118852.1
891 aa
Os07g0570300,  O.sativa
Os07g0570300
NP_001060044.1
988 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Anion activation site of insulin-degrading enzyme.
Noinaj N, et al. J Biol Chem 287, 48-57 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_M16 (pfam00675)
  Insulinase (Peptidase family M16).
Peptidase_M16_C (pfam05193)
  Peptidase M16 inactive domain.
Peptidase_M16 (pfam00675)
  Insulinase (Peptidase family M16).
Peptidase_M16_C (pfam05193)
  Peptidase M16 inactive domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ide includes H.sapiens IDE and R.norvegicus Ide.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (20 transcripts, 9 species)
Mammalia - mammals (15 transcripts, 12 species)
Amphibia - amphibians (4 transcripts, 2 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (5 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (45 transcripts, 31 species)
Liliopsida - monocots (17 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 2 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (3 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 1 species)

 

 

 

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