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HomoloGene:49486. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MYO3A,  H.sapiens
myosin IIIA
NP_059129.3
1616 aa
MYO3A,  P.troglodytes
myosin IIIA
XP_507703.2
1625 aa
MYO3A,  M.mulatta
myosin IIIA
XP_001101244.2
1623 aa
MYO3A,  C.lupus
myosin IIIA
XP_005617041.1
1614 aa
MYO3A,  B.taurus
myosin IIIA
XP_002692119.1
1623 aa
Myo3a,  M.musculus
myosin IIIA
NP_680779.3
1621 aa
Myo3a,  R.norvegicus
myosin IIIA
XP_574090.4
1614 aa
MYO3A,  G.gallus
myosin IIIA
XP_418597.3
1640 aa
myo3a,  X.tropicalis
myosin IIIA
XP_002933189.2
1573 aa
myo3a,  D.rerio
myosin IIIA
NP_991142.1
1775 aa
ninaC,  D.melanogaster
neither inactivation nor afterpotential C
NP_523503.2
1501 aa
AgaP_AGAP009730,  A.gambiae
AgaP_AGAP009730
XP_318814.4
1581 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal recessive 30.



Publications
Articles associated with genes and sequences of this homology group.

The kinase domain alters the kinetic properties of the myosin IIIA motor.
Dosé AC, et al. Biochemistry 47, 2485-96 (2008).
Kinetic mechanism of human myosin IIIA.
Dosé AC, et al. J Biol Chem 282, 216-31 (2007).
Human myosin III is a motor having an extremely high affinity for actin.
Kambara T, et al. J Biol Chem 281, 37291-301 (2006).
Cloning and chromosomal localization of a human class III myosin.
Dosé AC & Burnside B. Genomics 67, 333-42 (2000).
The growing family of myosin motors and their role in neurons and sensory cells.
Hasson T & Mooseker MS. Curr Opin Neurobiol 7, 615-23 (1997).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PhaP_Bmeg (cl09820)
  Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg).
IQ (cl15479)
  IQ calmodulin-binding motif.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
IQ (cl15479)
  Calmodulin-binding motif.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myo3a includes H.sapiens MYO3A and R.norvegicus RGD1560083.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Arthropoda
Insecta - insects (13 transcripts, 8 species)

Chordata
Mammalia - mammals (4 transcripts, 4 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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