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HomoloGene:6149. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PPP2R4,  H.sapiens
protein phosphatase 2A activator, regulatory subunit 4
NP_821067.1
323 aa
PPP2R4,  P.troglodytes
protein phosphatase 2A activator, regulatory subunit 4
XP_001163459.2
373 aa
PPP2R4,  C.lupus
protein phosphatase 2A activator, regulatory subunit 4
XP_548424.4
323 aa
PPP2R4,  B.taurus
protein phosphatase 2A activator, regulatory subunit 4
NP_001039638.1
324 aa
Ppp2r4,  M.musculus
protein phosphatase 2A activator, regulatory subunit B
NP_620087.3
323 aa
Ppp2r4,  R.norvegicus
protein phosphatase 2A activator, regulatory subunit 4
NP_001102047.1
323 aa
PPP2R4,  G.gallus
protein phosphatase 2A activator, regulatory subunit 4
NP_001026542.1
321 aa
ppp2r4,  X.tropicalis
protein phosphatase 2A activator, regulatory subunit 4
XP_004916736.1
360 aa
ppp2r4,  D.rerio
protein phosphatase 2A activator, regulatory subunit 4
NP_001003425.2
324 aa
Ptpa,  D.melanogaster
Phosphotyrosyl phosphatase activator
NP_523466.2
398 aa
AgaP_AGAP008652,  A.gambiae
AgaP_AGAP008652
XP_314749.4
360 aa
Y71H2AM.20,  C.elegans
Y71H2AM.20
NP_497617.1
375 aa
RRD2,  S.cerevisiae
RRD2
NP_015173.1
358 aa
KLLA0F11187g,  K.lactis
KLLA0F11187g
XP_455589.1
360 aa
AGOS_ACR139C,  E.gossypii
AGOS_ACR139C
NP_983541.1
359 aa
SPAC1782.05,  S.pombe
SPAC1782.05
NP_594712.1
352 aa
MGG_09935,  M.oryzae
MGG_09935
XP_003710037.1
449 aa
NCU03269,  N.crassa
NCU03269
XP_964422.1
449 aa
AT4G08960,  A.thaliana
AT4G08960
NP_567342.1
392 aa
Os06g0219800,  O.sativa
Os06g0219800
NP_001057165.1
396 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

PP2A and Alzheimer disease.
Torrent L & Ferrer I. Curr Alzheimer Res 9, 248-56 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTPA (cl03888)
  Phosphotyrosyl phosphatase activator (PTPA) is also known as protein phosphatase 2A (PP2A) phosphatase activator. PTPA is an essential, well conserved protein that stimulates the tyrosyl phosphatase activity of PP2A. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. Together, PTPA and PP2A constitute an ATPase. It has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA is controlled by the transcription factor Yin Yang1 (YY1). PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ppp2r4 includes H.sapiens PPP2R4 and R.norvegicus Ppp2r4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (18 transcripts, 17 species)
Actinopterygii - bony fishes (11 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (30 transcripts, 28 species)
Liliopsida - monocots (8 transcripts, 8 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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