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HomoloGene:229. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NPHP1,  H.sapiens
nephronophthisis 1 (juvenile)
NP_001121650.1
677 aa
NPHP1,  P.troglodytes
nephronophthisis 1 (juvenile)
XP_003309231.1
677 aa
NPHP1,  M.mulatta
nephronophthisis 1 (juvenile)
XP_002799426.1
679 aa
NPHP1,  C.lupus
nephronophthisis 1 (juvenile)
NP_001182770.1
694 aa
NPHP1,  B.taurus
nephronophthisis 1 (juvenile)
NP_001098802.1
686 aa
Nphp1,  M.musculus
nephronophthisis 1 (juvenile) homolog (human)
NP_058598.1
691 aa
Nphp1,  R.norvegicus
nephronophthisis 1 (juvenile)
NP_001099976.1
457 aa
NPHP1,  G.gallus
nephronophthisis 1 (juvenile)
NP_001186358.1
681 aa
nphp1,  X.tropicalis
nephronophthisis 1 (juvenile)
XP_002940386.2
685 aa
nphp1,  D.rerio
nephronophthisis 1
NP_001070638.1
667 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nephronophthisis, juvenile.
Senior-Loken syndrome-1.
Joubert syndrome 4.



Publications
Articles associated with genes and sequences of this homology group.

Nephronophthisis cannot be detected by urinary screening program.
Hirano D, et al. Clin Pediatr (Phila) 52, 759-61 (2013).
Nephronophthisis-like nephritis associated with fibrous dysplasia of bone.
Bacchetta J, et al. Pediatr Nephrol 23, 1559-63 (2008).
Nephronophthisis-associated ciliopathies.
Hildebrandt F & Zhou W. J Am Soc Nephrol 18, 1855-71 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nphp1 includes H.sapiens NPHP1 and R.norvegicus Nphp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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