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HomoloGene:31253. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DYRK1B,  H.sapiens
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
NP_004705.1
629 aa
DYRK1B,  P.troglodytes
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
XP_512657.2
629 aa
DYRK1B,  M.mulatta
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
XP_001089972.1
629 aa
DYRK1B,  C.lupus
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
XP_005616637.1
709 aa
DYRK1B,  B.taurus
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
NP_001074984.1
629 aa
Dyrk1b,  M.musculus
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
NP_001258299.1
689 aa
Dyrk1b,  R.norvegicus
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
NP_001100966.1
589 aa
dyrk1a.2,  X.tropicalis
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, gene 2
NP_001120373.1
671 aa
dyrk1b,  D.rerio
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
NP_001161737.1
681 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The kinase Mirk is a potential therapeutic target in osteosarcoma.
Yang C, et al. Carcinogenesis 31, 552-8 (2010).
Mirk regulates the exit of colon cancer cells from quiescence.
Jin K, et al. J Biol Chem 284, 22916-25 (2009).
Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts.
Mercer SE, et al. J Biol Chem 280, 25788-801 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dyrk1b includes H.sapiens DYRK1B and R.norvegicus Dyrk1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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