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HomoloGene:104136. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PIAS4,  H.sapiens
protein inhibitor of activated STAT, 4
510 aa
PIAS4,  C.lupus
protein inhibitor of activated STAT, 4
515 aa
PIAS4,  B.taurus
protein inhibitor of activated STAT, 4
513 aa
Pias4,  M.musculus
protein inhibitor of activated STAT 4
507 aa
Pias4,  R.norvegicus
protein inhibitor of activated STAT, 4
507 aa
PIAS4,  G.gallus
protein inhibitor of activated STAT, 4
491 aa
pias4,  X.tropicalis
protein inhibitor of activated STAT, 4
501 aa
pias4a,  D.rerio
protein inhibitor of activated STAT, 4a
505 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.
Naidu SR, et al. Cell Cycle 11, 2717-28 (2012).
PIASgamma is required for faithful chromosome segregation in human cells.
Díaz-Martínez LA, et al. PLoS One 1, e53 (2006).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-MIZ (pfam02891)
  MIZ/SP-RING zinc finger.
PINIT (pfam14324)
  PINIT domain.
PINIT (pfam14324)
  PINIT domain.
SAP (cl02640)
  The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pias4 includes H.sapiens PIAS4 and R.norvegicus Pias4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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