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HomoloGene:1746. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LRP5,  H.sapiens
low density lipoprotein receptor-related protein 5
NP_002326.2
1615 aa
LRP5,  P.troglodytes
low density lipoprotein receptor-related protein 5
XP_508605.3
1739 aa
LRP5,  C.lupus
low density lipoprotein receptor-related protein 5
XP_003432463.2
1762 aa
LRP5,  B.taurus
low density lipoprotein receptor-related protein 5
XP_002699451.2
1597 aa
Lrp5,  M.musculus
low density lipoprotein receptor-related protein 5
NP_032539.2
1614 aa
Lrp5,  R.norvegicus
low density lipoprotein receptor-related protein 5
NP_001099791.2
1600 aa
LRP5,  G.gallus
low density lipoprotein receptor-related protein 5
NP_001012915.1
1616 aa
lrp5,  X.tropicalis
low density lipoprotein receptor-related protein 5
XP_002941689.1
1603 aa
lrp5,  D.rerio
low density lipoprotein receptor-related protein 5
NP_001170929.1
1430 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperostosis, endosteal.
Osteosclerosis.
Osteoporosis.
Osteoporosis-pseudoglioma syndrome.
Exudative vitreoretinopathy 4.
Bone mineral density variability 1.
Osteopetrosis, AD type I.
van Buchem disease, type 2.



Publications
Articles associated with genes and sequences of this homology group.

Association of LRP5 haplotypes with osteoporosis in Mexican women.
Falcón-Ramírez E, et al. Mol Biol Rep 40, 2705-10 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ldl_recept_a (pfam00057)
  Low-density lipoprotein receptor domain class A.
Ldl_recept_b (cl10508)
  Low-density lipoprotein receptor repeat class B.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lrp5 includes H.sapiens LRP5 and R.norvegicus Lrp5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 3 species)

 

 

 

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