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HomoloGene:2185. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

UPF1,  H.sapiens
UPF1 regulator of nonsense transcripts homolog (yeast)
NP_002902.2
1118 aa
UPF1,  P.troglodytes
UPF1 regulator of nonsense transcripts homolog (yeast)
XP_512972.4
1057 aa
LOC720288,  M.mulatta
regulator of nonsense transcripts 1-like
XP_002808229.1
1096 aa
UPF1,  C.lupus
UPF1 regulator of nonsense transcripts homolog (yeast)
XP_005632737.1
1130 aa
UPF1,  B.taurus
UPF1 regulator of nonsense transcripts homolog (yeast)
XP_005208537.1
1127 aa
Upf1,  M.musculus
UPF1 regulator of nonsense transcripts homolog (yeast)
NP_001116301.1
1124 aa
Upf1,  R.norvegicus
UPF1 regulator of nonsense transcripts homolog (yeast)
XP_003751614.1
1124 aa
UPF1,  G.gallus
UPF1 regulator of nonsense transcripts homolog (yeast)
XP_418237.3
1096 aa
upf1,  X.tropicalis
regulator of nonsense transcripts 1
XP_002938872.2
1100 aa
upf1,  D.rerio
upf1 regulator of nonsense transcripts homolog (yeast)
NP_998639.1
1100 aa
Upf1,  D.melanogaster
Upf1
NP_572767.1
1180 aa
AgaP_AGAP001133,  A.gambiae
AgaP_AGAP001133
XP_322028.4
1161 aa
smg-2,  C.elegans
smg-2
NP_490829.1
1069 aa
NAM7,  S.cerevisiae
NAM7
NP_013797.1
971 aa
KLLA0B06435g,  K.lactis
KLLA0B06435g
XP_451821.1
969 aa
AGOS_ABR022C,  E.gossypii
AGOS_ABR022C
NP_982968.4
999 aa
upf1,  S.pombe
upf1
NP_593080.1
925 aa
MGG_00976,  M.oryzae
MGG_00976
XP_003717973.1
1105 aa
NCU04242,  N.crassa
NCU04242
XP_961233.1
1093 aa
LBA1,  A.thaliana
LBA1
NP_199512.2
1254 aa
Os07g0495900,  O.sativa
Os07g0495900
NP_001059698.1
1121 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Rules that govern UPF1 binding to mRNA 3' UTRs.
Kurosaki T & Maquat LE. Proc Natl Acad Sci U S A 110, 3357-62 (2013).
UPF1 involvement in nuclear functions.
Varsally W & Brogna S. Biochem Soc Trans 40, 778-83 (2012).
Up-frameshift protein 1 (UPF1): multitalented entertainer in RNA decay.
Imamachi N, et al. Drug Discov Ther 6, 55-61 (2012).
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
Melero R, et al. Nat Struct Mol Biol 19, 498-505, S1-2 (2012).
UPF1: a leader at the end of chromosomes.
Azzalin CM. Nucleus 3, 16-21 (2012).
Upf1 senses 3'UTR length to potentiate mRNA decay.
Hogg JR & Goff SP. Cell 143, 379-89 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DEC-1_N (pfam04625)
  DEC-1 protein, N-terminal region.
UPF1_Zn_bind (pfam09416)
  RNA helicase (UPF2 interacting domain).
AAA_11 (pfam13086)
  AAA domain.
AAA_12 (pfam13087)
  AAA domain.
AAA_12 (pfam13087)
  AAA domain.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Upf1 includes H.sapiens UPF1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (19 transcripts, 7 species)
Mammalia - mammals (17 transcripts, 11 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)
Arachnida - arachnids (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (38 transcripts, 21 species)
Liliopsida - monocots (12 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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