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HomoloGene:1858. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NBN,  H.sapiens
nibrin
NP_002476.2
754 aa
NBN,  P.troglodytes
nibrin
XP_519851.3
754 aa
NBN,  M.mulatta
nibrin
XP_001085033.1
754 aa
NBN,  C.lupus
nibrin
XP_005638161.1
747 aa
NBN,  B.taurus
nibrin
NP_001069305.2
754 aa
Nbn,  M.musculus
nibrin
NP_038780.3
751 aa
Nbn,  R.norvegicus
nibrin
NP_620228.1
750 aa
NBN,  G.gallus
nibrin
NP_989668.1
753 aa
nbn,  X.tropicalis
nibrin
XP_004915210.1
776 aa
nbn,  D.rerio
nibrin
NP_001014819.1
818 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Nijmegen breakage syndrome.
Leukemia, acute lymphoblastic.



Publications
Articles associated with genes and sequences of this homology group.

NBS1 directly activates ATR independently of MRE11 and TOPBP1.
Kobayashi M, et al. Genes Cells 18, 238-46 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Nbs1_C (pfam08599)
  DNA damage repair protein Nbs1.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
FHA (cl00062)
  Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nbn includes H.sapiens NBN and R.norvegicus Nbn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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