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HomoloGene:41336. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

GIT2,  H.sapiens
G protein-coupled receptor kinase interacting ArfGAP 2
NP_001128686.1
729 aa
GIT2,  P.troglodytes
G protein-coupled receptor kinase interacting ArfGAP 2
XP_001139823.2
602 aa
GIT2,  M.mulatta
G protein-coupled receptor kinase interacting ArfGAP 2
XP_001106038.1
759 aa
GIT2,  C.lupus
G protein-coupled receptor kinase interacting ArfGAP 2
XP_005636373.1
761 aa
GIT2,  B.taurus
G protein-coupled receptor kinase interacting ArfGAP 2
NP_001180030.1
759 aa
Git2,  M.musculus
G protein-coupled receptor kinase-interactor 2
NP_001070827.1
680 aa
Git2,  R.norvegicus
G protein-coupled receptor kinase interacting ArfGAP 2
NP_001005553.1
759 aa
GIT2,  G.gallus
G protein-coupled receptor kinase interactor 2
NP_989537.1
757 aa
git2,  X.tropicalis
G protein-coupled receptor kinase interacting ArfGAP 2
NP_001016917.1
729 aa
git2a,  D.rerio
G protein-coupled receptor kinase interactor 2a
NP_001119925.1
750 aa
Git,  D.melanogaster
Git
NP_610599.3
731 aa
AgaP_AGAP006888,  A.gambiae
AgaP_AGAP006888
XP_308871.4
713 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Regulation of thymocyte positive selection and motility by GIT2.
Phee H, et al. Nat Immunol 11, 503-11 (2010).
Anxiety-like behaviors in mice lacking GIT2.
Schmalzigaug R, et al. Neurosci Lett 451, 156-61 (2009).
Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues.
Schmalzigaug R, et al. J Histochem Cytochem 55, 1039-48 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GIT1_C (pfam12205)
  G protein-coupled receptor kinase-interacting protein 1 C term.
Shugoshin_N (pfam07558)
  Shugoshin N-terminal coiled-coil region.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
GIT_SHD (cl11983)
  Spa2 homology domain (SHD) of GIT.
ArfGap (pfam01412)
  Putative GTPase activating protein for Arf.
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
ArfGap (cl02464)
  Putative GTPase activating protein for Arf.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Git2 includes H.sapiens GIT2 and R.norvegicus Git2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (23 transcripts, 9 species)
Mammalia - mammals (11 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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