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HomoloGene:7715. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

FGF8,  H.sapiens
fibroblast growth factor 8 (androgen-induced)
244 aa
FGF8,  B.taurus
fibroblast growth factor 8 (androgen-induced)
244 aa
Fgf8,  M.musculus
fibroblast growth factor 8
244 aa
Fgf8,  R.norvegicus
fibroblast growth factor 8
204 aa
FGF8,  G.gallus
fibroblast growth factor 8 (androgen-induced)
214 aa
fgf8,  X.tropicalis
fibroblast growth factor 8 (androgen-induced)
211 aa
fgf8a,  D.rerio
fibroblast growth factor 8a
210 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Kallmann syndrome 6.

Articles associated with genes and sequences of this homology group.

Circumventing the polydactyly 'constraint': the mole's 'thumb'.
Mitgutsch C, et al. Biol Lett 8, 74-7 (2012).
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain.
Sunmonu NA, et al. J Cell Physiol 226, 1722-6 (2011).
FGF8 signaling is chemotactic for cardiac neural crest cells.
Sato A, et al. Dev Biol 354, 18-30 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FGF (cl00060)
  Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgf8 includes H.sapiens FGF8 and R.norvegicus Fgf8.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 5 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)




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