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HomoloGene:121565. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TPH1,  H.sapiens
tryptophan hydroxylase 1
NP_004170.1
444 aa
TPH1,  P.troglodytes
tryptophan hydroxylase 1
XP_521852.3
454 aa
TPH1,  M.mulatta
tryptophan hydroxylase 1
XP_001083991.2
885 aa
TPH1,  C.lupus
tryptophan hydroxylase 1
NP_001184120.1
444 aa
TPH1,  B.taurus
tryptophan hydroxylase 1
XP_005216133.1
480 aa
Tph1,  M.musculus
tryptophan hydroxylase 1
NP_033440.1
447 aa
Tph1,  R.norvegicus
tryptophan hydroxylase 1
NP_001094104.1
444 aa
TPH1,  G.gallus
tryptophan hydroxylase 1
NP_990287.1
445 aa
LOC100497239,  X.tropicalis
tryptophan 5-hydroxylase-like
XP_002942733.1
460 aa
tph1b,  D.rerio
tryptophan hydroxylase 1b
NP_001001843.2
480 aa
tph1a,  D.rerio
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
NP_840091.1
471 aa
Trh,  D.melanogaster
Tryptophan hydroxylase
NP_612080.1
555 aa
AgaP_AGAP006020,  A.gambiae
AgaP_AGAP006020
XP_316057.3
531 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

TPH1 A218C polymorphism and temperament in major depression.
Andre K, et al. BMC Psychiatry 13, 118 (2013).
Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice.
Abid S, et al. Am J Physiol Lung Cell Mol Physiol 303, L500-8 (2012).
Decreased osteoclastogenesis in serotonin-deficient mice.
Chabbi-Achengli Y, et al. Proc Natl Acad Sci U S A 109, 2567-72 (2012).
Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice.
Amireault P, et al. Proc Natl Acad Sci U S A 108, 13141-6 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ACT (cl09141)
  ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme.
RCC1 (pfam00415)
  Regulator of chromosome condensation (RCC1) repeat.
RCC1_2 (pfam13540)
  Regulator of chromosome condensation (RCC1) repeat.
arom_aa_hydroxylase (cl01244)
  Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan ...
ACT (cl09141)
  ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tph1 includes H.sapiens TPH1 and R.norvegicus Tph1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (10 transcripts, 7 species)
Mammalia - mammals (9 transcripts, 8 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Bryopsida - mosses (1 transcript, 1 species)
Coniferopsida - conifers (1 transcript, 1 species)

 

 

 

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