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HomoloGene:48773. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AKT2,  H.sapiens
v-akt murine thymoma viral oncogene homolog 2
NP_001617.1
481 aa
AKT2,  P.troglodytes
v-akt murine thymoma viral oncogene homolog 2
XP_001143709.2
481 aa
AKT2,  M.mulatta
v-akt murine thymoma viral oncogene homolog 2
XP_001093461.1
481 aa
AKT2,  C.lupus
v-akt murine thymoma viral oncogene homolog 2
NP_001012340.1
419 aa
AKT2,  B.taurus
v-akt murine thymoma viral oncogene homolog 2
NP_001193075.1
481 aa
Akt2,  M.musculus
thymoma viral proto-oncogene 2
NP_001103678.1
481 aa
Akt2,  R.norvegicus
v-akt murine thymoma viral oncogene homolog 2
NP_058789.1
481 aa
akt2,  X.tropicalis
v-akt murine thymoma viral oncogene homolog 2
NP_001116936.1
485 aa
akt2,  D.rerio
v-akt murine thymoma viral oncogene homolog 2
NP_937789.1
479 aa
Akt1,  D.melanogaster
Akt1
NP_732114.1
530 aa
AgaP_AGAP002161,  A.gambiae
AgaP_AGAP002161
XP_308030.5
571 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, type II.



Publications
Articles associated with genes and sequences of this homology group.

Akt2 regulates metastatic potential in neuroblastoma.
Qiao J, et al. PLoS One 8, e56382 (2013).
Regulation of Na+/H+ exchanger in dendritic cells by Akt2.
Bhandaru M, et al. Pflugers Arch 463, 355-63 (2012).
Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.
Wani R, et al. Proc Natl Acad Sci U S A 108, 10550-5 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PH-like (cl00273)
  Pleckstrin homology-like domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Akt2 includes H.sapiens AKT2 and R.norvegicus Akt2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (19 transcripts, 8 species)
Mammalia - mammals (11 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (3 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

 

 

 

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