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HomoloGene:5534. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

D2HGDH,  H.sapiens
D-2-hydroxyglutarate dehydrogenase
NP_689996.4
521 aa
D2HGDH,  P.troglodytes
D-2-hydroxyglutarate dehydrogenase
XP_001162772.3
601 aa
LOC702028,  M.mulatta
d-2-hydroxyglutarate dehydrogenase, mitochondrial-like
XP_001094865.2
695 aa
D2HGDH,  C.lupus
D-2-hydroxyglutarate dehydrogenase
XP_005636042.1
433 aa
D2HGDH,  B.taurus
D-2-hydroxyglutarate dehydrogenase
NP_001069446.1
544 aa
D2hgdh,  M.musculus
D-2-hydroxyglutarate dehydrogenase
NP_849213.2
535 aa
D2hgdh,  R.norvegicus
D-2-hydroxyglutarate dehydrogenase
NP_001100396.1
528 aa
D2HGDH,  G.gallus
D-2-hydroxyglutarate dehydrogenase
XP_422664.3
548 aa
d2hgdh,  X.tropicalis
D-2-hydroxyglutarate dehydrogenase
XP_002936654.1
525 aa
d2hgdh,  D.rerio
D-2-hydroxyglutarate dehydrogenase
NP_001074066.1
533 aa
CG3835,  D.melanogaster
CG3835
NP_569982.1
533 aa
AgaP_AGAP004195,  A.gambiae
AgaP_AGAP004195
XP_313089.4
517 aa
AgaP_AGAP004189,  A.gambiae
AgaP_AGAP004189
XP_001230873.3
371 aa
CELE_F54D5.12,  C.elegans
CELE_F54D5.12
NP_496465.1
487 aa
DLD2,  S.cerevisiae
DLD2
NP_010103.1
530 aa
KLLA0F05753g,  K.lactis
KLLA0F05753g
XP_455341.1
543 aa
AGOS_ACL021C,  E.gossypii
AGOS_ACL021C
NP_983383.1
534 aa
SPBC713.03,  S.pombe
SPBC713.03
NP_595342.1
526 aa
MGG_12830,  M.oryzae
MGG_12830
XP_003717091.1
544 aa
NCU06441,  N.crassa
NCU06441
XP_957332.1
551 aa
AT4G36400,  A.thaliana
AT4G36400
NP_568003.2
559 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
D-2-hydroxyglutaric aciduria.



Publications
Articles associated with genes and sequences of this homology group.

Mutations in phenotypically mild D-2-hydroxyglutaric aciduria.
Struys EA, et al. Ann Neurol 58, 626-30 (2005).
Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations.
Brehmer S, et al. Neuropathol Appl Neurobiol 37, 330-2 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FAD_binding_4 (pfam01565)
  FAD binding domain.
FAD-oxidase_C (pfam02913)
  FAD linked oxidases, C-terminal domain.
FAM53 (pfam15242)
  Family of FAM53.
FAD_binding_4 (cl19922)
  FAD binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus D2hgdh includes H.sapiens D2HGDH and R.norvegicus D2hgdh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 8 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (24 transcripts, 20 species)
Liliopsida - monocots (9 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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