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HomoloGene:37592. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

ITGA7,  H.sapiens
integrin, alpha 7
1137 aa
ITGA7,  P.troglodytes
integrin, alpha 7
1137 aa
ITGA7,  C.lupus
integrin, alpha 7
1181 aa
ITGA7,  B.taurus
integrin, alpha 7
1144 aa
Itga7,  M.musculus
integrin alpha 7
1136 aa
Itga7,  R.norvegicus
integrin, alpha 7
1135 aa
itga7,  X.tropicalis
integrin, alpha 7
1111 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Myopathy, congenital.

Articles associated with genes and sequences of this homology group.

Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle.
Boppart MD, et al. Am J Physiol Regul Integr Comp Physiol 295, R1623-30 (2008).
Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury.
Boppart MD, et al. Am J Physiol Cell Physiol 290, C1660-5 (2006).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (pfam13517)
  Family description.
FG-GAP (cl15299)
  FG-GAP repeat.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (cl15299)
  This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itga7 includes H.sapiens ITGA7 and R.norvegicus Itga7.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 9 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Chromadorea - nematodes (2 transcripts, 1 species)




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