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HomoloGene:68096. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IMPDH1,  H.sapiens
IMP (inosine 5'-monophosphate) dehydrogenase 1
NP_000874.2
599 aa
IMPDH1,  P.troglodytes
IMP (inosine 5'-monophosphate) dehydrogenase 1
XP_003951173.1
599 aa
LOC701039,  M.mulatta
inosine-5'-monophosphate dehydrogenase 1-like
XP_002803509.1
566 aa
IMPDH1,  C.lupus
IMP (inosine 5'-monophosphate) dehydrogenase 1
XP_003639517.2
622 aa
IMPDH1,  B.taurus
IMP (inosine 5'-monophosphate) dehydrogenase 1
NP_001071309.1
571 aa
Impdh1,  M.musculus
inosine 5'-phosphate dehydrogenase 1
NP_035959.2
514 aa
Impdh1,  R.norvegicus
IMP (inosine 5'-monophosphate) dehydrogenase 1
NP_001102089.1
548 aa
impdh1,  X.tropicalis
IMP (inosine 5'-monophosphate) dehydrogenase 1
NP_001017283.1
514 aa
impdh1b,  D.rerio
inosine 5'-phosphate dehydrogenase 1b
NP_001014391.1
514 aa
impdh1a,  D.rerio
inosine 5'-phosphate dehydrogenase 1a
NP_001002177.1
544 aa
ras,  D.melanogaster
raspberry
NP_001259427.1
537 aa
AgaP_AGAP011133,  A.gambiae
AgaP_AGAP011133
XP_309514.2
538 aa
T22D1.3,  C.elegans
T22D1.3
NP_001023395.1
534 aa
IMD4,  S.cerevisiae
IMD4
NP_013656.1
524 aa
IMD2,  S.cerevisiae
IMD2
NP_012088.3
523 aa
IMD3,  S.cerevisiae
IMD3
NP_013536.3
523 aa
KLLA0B05511g,  K.lactis
KLLA0B05511g
XP_451781.1
523 aa
AGOS_AER117W,  E.gossypii
AGOS_AER117W
NP_984977.2
522 aa
gua1,  S.pombe
gua1
NP_595702.1
524 aa
MGG_03699,  M.oryzae
MGG_03699
XP_003716182.1
543 aa
NCU03117,  N.crassa
NCU03117
XP_964976.1
536 aa
AT1G16350,  A.thaliana
AT1G16350
NP_173085.1
502 aa
AT1G79470,  A.thaliana
AT1G79470
NP_178065.1
503 aa
Os03g0780500,  O.sativa
Os03g0780500
NP_001051450.1
220 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Defective in pteridine synthesis; eye color dark ruby. Appears to affect the level of guanosine triphosphate cyclohydrolase activity; ras alleles exhibit increased activity compared to wild type at pupariation, but decreased activity at eclosion (Evans and Howell, 1979). Not a purine auxotroph. Color autonomous in larval optic discs transplanted into wild-type hosts (Beadle and Ephrussi, 1936). ras/rasl* display ras eye color. Larval Malpighian tubes nearly wild type; not useful for classification (Brehme and Demerec, 1942). (See FlyBase for complete description.)

H.sapiens
Leber congenital amaurosis XI.
Retinitis pigmentosa-10.



Publications
Articles associated with genes and sequences of this homology group.

Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa.
McGrew DA & Hedstrom L. Adv Exp Med Biol 723, 539-45 (2012).
Mutation frequency of IMPDH1 gene of Han population in Ganzhou City.
Shumei L, et al. Adv Exp Med Biol 664, 293-7 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TIM_phosphate_binding (cl09108)
  TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
IMP_dehydrog (TIGR01302)
  inosine-5'-monophosphate dehydrogenase.
PTZ00314 (PTZ00314)
  inosine-5'-monophosphate dehydrogenase; Provisional.
CBS_pair (cl15354)
  The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
TIM_phosphate_binding (cl17186)
  TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
CBS_pair (cl15354)
  The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
TIM_phosphate_binding (cl17186)
  TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Impdh1 includes H.sapiens IMPDH1 and R.norvegicus Impdh1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 9 species)
Mammalia - mammals (10 transcripts, 8 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 9 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (3 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (10 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (4 transcripts, 3 species)
Coniferopsida - conifers (3 transcripts, 2 species)
Eudicotyledons - eudicots (1 transcript, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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