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HomoloGene:10119. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

UBE2W,  H.sapiens
ubiquitin-conjugating enzyme E2W (putative)
NP_060769.4
180 aa
UBE2W,  P.troglodytes
ubiquitin-conjugating enzyme E2W (putative)
XP_519809.4
188 aa
UBE2W,  M.mulatta
ubiquitin-conjugating enzyme E2W (putative)
XP_001085749.2
180 aa
UBE2W,  C.lupus
ubiquitin-conjugating enzyme E2W (putative)
XP_544128.3
180 aa
UBE2W,  B.taurus
ubiquitin-conjugating enzyme E2W (putative)
NP_001092592.1
151 aa
Ube2w,  M.musculus
ubiquitin-conjugating enzyme E2W (putative)
NP_080049.2
180 aa
Ube2wl,  R.norvegicus
ubiquitin-conjugating enzyme E2W-like
XP_001057119.2
287 aa
UBE2W,  G.gallus
ubiquitin-conjugating enzyme E2W (putative)
NP_001186410.1
151 aa
ube2w,  X.tropicalis
ubiquitin-conjugating enzyme E2W (putative)
NP_001016132.1
151 aa
flj11011l,  D.rerio
hypothetical protein FLJ11011-like (H. sapiens)
NP_001038758.2
151 aa
CG7220,  D.melanogaster
CG7220
NP_724964.2
190 aa
AgaP_AGAP005324,  A.gambiae
AgaP_AGAP005324
XP_315339.4
229 aa
ubc-16,  C.elegans
ubc-16
NP_493587.1
152 aa
UBC16,  A.thaliana
UBC16
NP_565110.1
161 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.
Sigdel TK, et al. Clin J Am Soc Nephrol 6, 2775-84 (2011).
Building ubiquitin chains: E2 enzymes at work.
Ye Y & Rape M. Nat Rev Mol Cell Biol 10, 755-64 (2009).
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.
Starita LM, et al. Proc Natl Acad Sci U S A 110, E1263-72 (2013).
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP.
Scaglione KM, et al. Mol Cell 43, 599-612 (2011).
Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.
Tatham MH, et al. Biochem J 453, 137-45 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
UBCc (cl00154)
  Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ube2w includes H.sapiens UBE2W.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (35 transcripts, 24 species)
Coniferopsida - conifers (9 transcripts, 3 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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