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HomoloGene:1966. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

PER1,  H.sapiens
period circadian clock 1
1290 aa
PER1,  P.troglodytes
period homolog 1 (Drosophila)
1290 aa
PER1,  M.mulatta
period homolog 1 (Drosophila)
1292 aa
PER1,  C.lupus
period circadian clock 1
1294 aa
PER1,  B.taurus
period circadian clock 1
1284 aa
Per1,  M.musculus
period circadian clock 1
1291 aa
Per1,  R.norvegicus
period circadian clock 1
1293 aa
per1,  X.tropicalis
period circadian clock 1
1236 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

The absence of melanopsin alters retinal clock function and dopamine regulation by light.
Dkhissi-Benyahya O, et al. Cell Mol Life Sci 70, 3435-47 (2013).
Excess androgen during puberty disrupts circadian organization in female rats.
Sellix MT, et al. Endocrinology 154, 1636-47 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Period_C (pfam12114)
  Period protein 2/3C-terminal region.
PAS (cd00130)
  PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
Period_C (pfam12114)
  Period protein 2/3C-terminal region.
PAS_11 (pfam14598)
  PAS domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Per1 includes H.sapiens PER1 and R.norvegicus Per1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (17 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Amphibia - amphibians (1 transcript, 1 species)




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