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HomoloGene:7594. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

VCL,  H.sapiens
vinculin
NP_054706.1
1134 aa
VCL,  P.troglodytes
vinculin
XP_507854.2
1134 aa
VCL,  M.mulatta
vinculin
XP_001118118.1
547 aa
VCL,  C.lupus
vinculin
XP_536395.3
1170 aa
VCL,  B.taurus
vinculin
NP_001178299.1
1134 aa
Vcl,  M.musculus
vinculin
NP_033528.3
1066 aa
Vcl,  R.norvegicus
vinculin
NP_001100718.1
1066 aa
VCL,  G.gallus
vinculin
NP_990772.1
1066 aa
vcl,  X.tropicalis
vinculin
NP_001090722.1
1065 aa
vcla,  D.rerio
vinculin a
NP_001122153.1
1131 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardiomyopathy, dilated, 1W.



Publications
Articles associated with genes and sequences of this homology group.

How vinculin regulates force transmission.
Dumbauld DW, et al. Proc Natl Acad Sci U S A 110, 9788-93 (2013).
Novel role for vinculin in ventricular myocyte mechanics and dysfunction.
Tangney JR, et al. Biophys J 104, 1623-33 (2013).
Metavinculin: New insights into functional properties of a muscle adhesion protein.
Thoss F, et al. Biochem Biophys Res Commun 430, 7-13 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Vinculin (pfam01044)
  Vinculin family.
Vinculin (pfam01044)
  Vinculin family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vcl includes H.sapiens VCL and R.norvegicus Vcl.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (13 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

 

 

 

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