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HomoloGene:21661. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FHIT,  H.sapiens
fragile histidine triad
NP_001159715.1
147 aa
FHIT,  P.troglodytes
fragile histidine triad
XP_001156390.2
147 aa
FHIT,  M.mulatta
fragile histidine triad
XP_001094642.1
149 aa
FHIT,  C.lupus
fragile histidine triad
NP_001135729.1
149 aa
FHIT,  B.taurus
fragile histidine triad gene
NP_001035736.1
149 aa
Fhit,  M.musculus
fragile histidine triad gene
NP_034340.1
150 aa
Fhit,  R.norvegicus
fragile histidine triad
NP_068542.1
150 aa
FHIT,  G.gallus
fragile histidine triad
NP_001264731.1
148 aa
fhit,  X.tropicalis
fragile histidine triad
NP_001006883.1
148 aa
fhit,  D.rerio
fragile histidine triad gene
NP_957034.1
150 aa
LOC100331277,  D.rerio
bis(5'-adenosyl)-triphosphatase-like
XP_002662597.1
150 aa
HNT2,  S.cerevisiae
HNT2
NP_010591.1
217 aa
KLLA0C10142g,  K.lactis
KLLA0C10142g
XP_452651.1
190 aa
AGOS_AAL053C,  E.gossypii
AGOS_AAL053C
NP_982489.2
186 aa
aph1,  S.pombe
aph1
NP_587836.1
182 aa
MGG_01517,  M.oryzae
MGG_01517
XP_003714490.1
280 aa
FHIT,  A.thaliana
FHIT
NP_200632.2
180 aa
Os11g0120600,  O.sativa
Os11g0120600
NP_001065609.2
151 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Genetic instability of the tumor suppressor gene FHIT in normal human cells.
Palumbo E, et al. Genes Chromosomes Cancer 52, 832-44 (2013).
The expression of FHIT in salivary carcinoma ex pleomorphic adenoma.
Kujan O, et al. Anticancer Res 32, 3147-52 (2012).
Aberrant FHIT expression is linked to bladder carcinogenesis and apoptosis.
Han Y, et al. Asian Pac J Cancer Prev 12, 2915-20 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HIT_like (cl00228)
  HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fhit includes H.sapiens FHIT and R.norvegicus Fhit.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (36 transcripts, 28 species)
Liliopsida - monocots (12 transcripts, 8 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 1 species)
Insecta - insects (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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