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HomoloGene:4100. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RGS4,  H.sapiens
regulator of G-protein signaling 4
NP_001095915.1
302 aa
RGS4,  P.troglodytes
regulator of G-protein signaling 4
XP_513957.2
302 aa
RGS4,  M.mulatta
regulator of G-protein signaling 4
XP_001082467.1
302 aa
RGS4,  C.lupus
regulator of G-protein signaling 4
XP_545783.2
205 aa
RGS4,  B.taurus
regulator of G-protein signaling 4
NP_001040065.1
205 aa
Rgs4,  M.musculus
regulator of G-protein signaling 4
NP_033088.2
205 aa
Rgs4,  R.norvegicus
regulator of G-protein signaling 4
NP_058910.1
205 aa
RGS4,  G.gallus
regulator of G-protein signaling 4
NP_989716.1
208 aa
rgs4,  X.tropicalis
regulator of G-protein signaling 4
NP_989295.2
243 aa
rgs4,  D.rerio
regulator of G-protein signalling 4
NP_954968.1
215 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Schizophrenia, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.
Ruiz de Azua I, et al. Proc Natl Acad Sci U S A 107, 7999-8004 (2010).
RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity.
Siedlecki A, et al. Am J Transplant 10, 231-41 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RGS (cl02565)
  Regulator of G protein signaling (RGS) domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rgs4 includes H.sapiens RGS4 and R.norvegicus Rgs4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)

 

 

 

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