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HomoloGene:56571. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SLC17A5,  H.sapiens
solute carrier family 17 (acidic sugar transporter), member 5
NP_036566.1
495 aa
SLC17A5,  P.troglodytes
solute carrier family 17 (anion/sugar transporter), member 5
XP_003311453.1
495 aa
SLC17A5,  M.mulatta
solute carrier family 17 (anion/sugar transporter), member 5
XP_001112868.1
495 aa
SLC17A5,  C.lupus
solute carrier family 17 (acidic sugar transporter), member 5
XP_005627590.1
502 aa
SLC17A5,  B.taurus
solute carrier family 17 (anion/sugar transporter), member 5
NP_001192903.1
495 aa
Slc17a5,  M.musculus
solute carrier family 17 (anion/sugar transporter), member 5
NP_766361.1
495 aa
Slc17a5,  R.norvegicus
solute carrier family 17 (acidic sugar transporter), member 5
NP_001009713.1
495 aa
SLC17A5,  G.gallus
solute carrier family 17 (anion/sugar transporter), member 5
NP_001026257.1
484 aa
slc17a5,  X.tropicalis
solute carrier family 17 (acidic sugar transporter), member 5
NP_001072823.1
496 aa
slc17a5,  D.rerio
solute carrier family 17 (anion/sugar transporter), member 5
NP_001070195.1
488 aa
MFS10,  D.melanogaster
Major Facilitator Superfamily Transporter 10
NP_572857.1
559 aa
C38C10.2,  C.elegans
C38C10.2
NP_499065.1
493 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sialic acid storage disorder, infantile.
Salla disease.



Publications
Articles associated with genes and sequences of this homology group.

Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5).
Lodder-Gadaczek J, et al. Biochem J 454, 31-8 (2013).
Successful prediction of substrate-binding pocket in SLC17 transporter sialin.
Pietrancosta N, et al. J Biol Chem 287, 11489-97 (2012).
Free Sialic Acid Storage Disorders
Adams D, et al. (1993).
Free sialic acid storage disease without sialuria.
Mochel F, et al. Ann Neurol 65, 753-7 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
2A0114euk (TIGR00894)
  Na(+)-dependent inorganic phosphate cotransporter.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc17a5 includes H.sapiens SLC17A5 and R.norvegicus Slc17a5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 8 species)
Arachnida - arachnids (3 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (3 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (3 transcripts, 1 species)
Hirudinida - segmented worms (3 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (47 transcripts, 29 species)
Liliopsida - monocots (12 transcripts, 8 species)
Coniferopsida - conifers (5 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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