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HomoloGene:717. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PLAT,  H.sapiens
plasminogen activator, tissue
NP_000921.1
562 aa
PLAT,  P.troglodytes
plasminogen activator, tissue
XP_528120.3
562 aa
PLAT,  M.mulatta
plasminogen activator, tissue
XP_001095260.1
516 aa
PLAT,  C.lupus
plasminogen activator, tissue
XP_539955.3
564 aa
PLAT,  B.taurus
plasminogen activator, tissue
NP_776571.2
566 aa
Plat,  M.musculus
plasminogen activator, tissue
NP_032898.2
559 aa
Plat,  R.norvegicus
plasminogen activator, tissue
NP_037283.2
559 aa
PLAT,  G.gallus
plasminogen activator, tissue
XP_004947670.1
567 aa
plat,  X.tropicalis
plasminogen activator, tissue
NP_001025574.2
560 aa
plat,  D.rerio
plasminogen activator, tissue
XP_002663097.1
578 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Plasminogen activator deficiency.



Publications
Articles associated with genes and sequences of this homology group.

tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis.
Valle-Garay E, et al. J Infect Dis 208, 218-23 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
FN1 (cl00063)
  Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.
KR (cl00100)
  Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Plat includes H.sapiens PLAT and R.norvegicus Plat.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 8 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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