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HomoloGene:441. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

KCNJ11,  H.sapiens
potassium inwardly-rectifying channel, subfamily J, member 11
NP_000516.3
390 aa
KCNJ11,  P.troglodytes
potassium inwardly-rectifying channel, subfamily J, member 11
XP_521849.2
390 aa
KCNJ11,  M.mulatta
potassium inwardly-rectifying channel, subfamily J, member 11
XP_001089155.1
390 aa
KCNJ11,  C.lupus
potassium inwardly-rectifying channel, subfamily J, member 11
XP_542519.2
333 aa
KCNJ11,  B.taurus
potassium inwardly-rectifying channel, subfamily J, member 11
NP_001075067.1
388 aa
Kcnj11,  M.musculus
potassium inwardly rectifying channel, subfamily J, member 11
NP_034732.1
390 aa
Kcnj11,  R.norvegicus
potassium inwardly rectifying channel, subfamily J, member 11
NP_112648.2
390 aa
KCNJ11,  G.gallus
potassium inwardly-rectifying channel, subfamily J, member 11
XP_426402.4
405 aa
LOC100492679,  X.tropicalis
ATP-sensitive inward rectifier potassium channel 11-like
XP_004916335.1
394 aa
kcnj11,  D.rerio
potassium inwardly-rectifying channel, subfamily J, member 11
NP_001034916.1
381 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, permanent neonatal, with neurologic features, 606176, {Diabetes mellitus, type 2, susceptibility to.
Hyperinsulinemic hypoglycemia, familial, 2.
Diabetes, permanent neonatal.
Diabetes mellitus, transient neonatal, 3.



Publications
Articles associated with genes and sequences of this homology group.

Pregabalin attenuates excitotoxicity in diabetes.
Huang CW, et al. PLoS One 8, e65154 (2013).
Cephalic phase insulin secretion is KATP channel independent.
Seino Y, et al. J Endocrinol 218, 25-33 (2013).
Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.
Wojtovich AP, et al. Am J Physiol Heart Circ Physiol 304, H1439-45 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IRK (pfam01007)
  Inward rectifier potassium channel.
IRK (pfam01007)
  Inward rectifier potassium channel.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcnj11 includes H.sapiens KCNJ11 and R.norvegicus Kcnj11.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 6 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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