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HomoloGene:113300. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HTRA2,  H.sapiens
HtrA serine peptidase 2
NP_037379.1
458 aa
HTRA2,  P.troglodytes
HtrA serine peptidase 2
XP_003309140.2
324 aa
HTRA2,  M.mulatta
HtrA serine peptidase 2
XP_001110803.1
458 aa
HTRA2,  C.lupus
HtrA serine peptidase 2
XP_532992.3
458 aa
HTRA2,  B.taurus
HtrA serine peptidase 2
NP_001071424.1
458 aa
Htra2,  M.musculus
HtrA serine peptidase 2
NP_062726.3
458 aa
Htra2,  R.norvegicus
HtrA serine peptidase 2
NP_001100069.1
458 aa
HTRA2,  G.gallus
HtrA serine peptidase 2
XP_423666.3
339 aa
LOC560917,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_002663637.2
308 aa
zgc:173425,  D.rerio
zgc:173425
NP_001098612.1
200 aa
LOC100149563,  D.rerio
uncharacterized LOC100149563
NP_001122292.1
195 aa
si:busm1-sl7.7,  D.rerio
si:busm1-sl7.7
XP_003199743.1
200 aa
zgc:174193,  D.rerio
zgc:174193
NP_001108178.1
200 aa
LOC100536969,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_003199752.2
200 aa
LOC793110,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_001332804.5
201 aa
LOC793521,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_001333305.1
211 aa
LOC100003308,  D.rerio
serine protease HTRA2, mitochondrial-like
NP_001103205.1
200 aa
si:dkey-33c12.10,  D.rerio
si:dkey-33c12.10
XP_003199749.2
197 aa
LOC797799,  D.rerio
novel serine protease protein
NP_001103998.1
266 aa
si:dkey-33c12.2,  D.rerio
si:dkey-33c12.2
XP_005172803.1
310 aa
LOC100329860,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_002664149.3
351 aa
LOC799006,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_001339411.5
294 aa
LOC797876,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_001923767.4
326 aa
LOC100331049,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_002665901.2
301 aa
si:dkey-84o3.3,  D.rerio
si:dkey-84o3.3
XP_002665896.3
200 aa
si:dkey-84o3.7,  D.rerio
si:dkey-84o3.7
XP_001335201.1
200 aa
LOC799537,  D.rerio
serine protease HTRA2, mitochondrial-like
NP_001103640.1
195 aa
LOC100330919,  D.rerio
serine protease HTRA2, mitochondrial-like
XP_005161042.1
209 aa
HtrA2,  D.melanogaster
HtrA2
NP_001262565.1
422 aa
AgaP_AGAP000240,  A.gambiae
AgaP_AGAP000240
XP_310886.5
433 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Parkinson disease 13.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trypsin_2 (pfam13365)
  Trypsin-like peptidase domain.
Tryp_SPc (cl00149)
  Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
Trypsin_2 (cl19303)
  Trypsin-like peptidase domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Htra2 includes H.sapiens HTRA2 and R.norvegicus Htra2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (18 transcripts, 8 species)
Mammalia - mammals (14 transcripts, 11 species)
Amphibia - amphibians (6 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Streptophyta
Coniferopsida - conifers (1 transcript, 1 species)

 

 

 

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