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HomoloGene:4706. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PRPF8,  H.sapiens
pre-mRNA processing factor 8
NP_006436.3
2335 aa
PRPF8,  M.mulatta
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
XP_001117328.1
2324 aa
PRPF8,  C.lupus
pre-mRNA processing factor 8
XP_854384.1
2335 aa
PRPF8,  B.taurus
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
NP_001099108.1
2335 aa
Prpf8,  M.musculus
pre-mRNA processing factor 8
NP_619600.2
2335 aa
Prpf8,  R.norvegicus
pre-mRNA processing factor 8
NP_001178519.1
2335 aa
PRPF8,  G.gallus
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
XP_415805.2
2335 aa
prpf8,  X.tropicalis
pre-mRNA processing factor 8
XP_002936105.1
2335 aa
prpf8,  D.rerio
pre-mRNA processing factor 8
NP_957270.2
2342 aa
Prp8,  D.melanogaster
pre-mRNA processing factor 8
NP_610735.1
2396 aa
AgaP_AGAP006885,  A.gambiae
AgaP_AGAP006885
XP_308873.2
2388 aa
prp-8,  C.elegans
prp-8
NP_498785.1
2329 aa
PRP8,  S.cerevisiae
PRP8
NP_012035.1
2413 aa
KLLA0A05280g,  K.lactis
KLLA0A05280g
XP_451233.1
2411 aa
AGOS_ABR207W,  E.gossypii
AGOS_ABR207W
NP_983156.2
2402 aa
spp42,  S.pombe
spp42
NP_593861.1
2363 aa
MGG_05244,  M.oryzae
MGG_05244
XP_003712798.1
2373 aa
NCU07832,  N.crassa
NCU07832
XP_962953.1
2374 aa
SUS2,  A.thaliana
SUS2
NP_178124.2
2359 aa
AT4G38780,  A.thaliana
AT4G38780
NP_195589.2
2332 aa
Os06g0167000,  O.sativa
Os06g0167000
NP_001056917.1
1099 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Retinitis pigmentosa-13.



Publications
Articles associated with genes and sequences of this homology group.

Structural elucidation of a PRP8 core domain from the heart of the spliceosome.
Ritchie DB, et al. Nat Struct Mol Biol 15, 1199-205 (2008).
Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.
Yang K, et al. Proc Natl Acad Sci U S A 105, 13817-22 (2008).
Prp8 protein: at the heart of the spliceosome.
Grainger RJ & Beggs JD. RNA 11, 533-57 (2005).
Proteomic analysis of interchromatin granule clusters.
Saitoh N, et al. Mol Biol Cell 15, 3876-90 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PROCN (pfam08083)
  PROCN (NUC071) domain.
U5_2-snRNA_bdg (pfam10597)
  U5-snRNA binding site 2 of PrP8.
PRO8NT (pfam08082)
  PRO8NT (NUC069), PrP8 N-terminal domain.
U6-snRNA_bdg (pfam10596)
  U6-snRNA interacting domain of PrP8.
PRP8_domainIV (pfam12134)
  PRP8 domain IV core.
RRM_4 (pfam10598)
  RNA recognition motif of the spliceosomal PrP8.
U6-snRNA_bdg (pfam10596)
  U6-snRNA interacting domain of PrP8.
MPN (cl13996)
  Mpr1p, Pad1p N-terminal (MPN) domains.
RNase_H_like (cl14782)
  Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prpf8 includes H.sapiens PRPF8 and R.norvegicus Prpf8.

 

 

 

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