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HomoloGene:84. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DLD,  H.sapiens
dihydrolipoamide dehydrogenase
NP_000099.2
509 aa
DLD,  P.troglodytes
dihydrolipoamide dehydrogenase
XP_001165051.2
538 aa
DLD,  M.mulatta
dihydrolipoamide dehydrogenase
XP_001095232.2
486 aa
DLD,  C.lupus
dihydrolipoamide dehydrogenase
NP_001003294.1
509 aa
DLD,  B.taurus
dihydrolipoamide dehydrogenase
NP_001193099.1
509 aa
Dld,  M.musculus
dihydrolipoamide dehydrogenase
NP_031887.2
509 aa
Dld,  R.norvegicus
dihydrolipoamide dehydrogenase
NP_955417.1
509 aa
DLD,  G.gallus
dihydrolipoamide dehydrogenase
NP_001025898.1
508 aa
dld,  X.tropicalis
dihydrolipoamide dehydrogenase
XP_002933161.2
509 aa
dldh,  D.rerio
dihydrolipoamide dehydrogenase
NP_958914.1
507 aa
CG7430,  D.melanogaster
CG7430
NP_649017.1
504 aa
AgaP_AGAP011629,  A.gambiae
AgaP_AGAP011629
XP_320877.4
433 aa
dld-1,  C.elegans
dld-1
NP_001255810.1
495 aa
LPD1,  S.cerevisiae
LPD1
NP_116635.1
499 aa
KLLA0D11154g,  K.lactis
KLLA0D11154g
XP_453559.1
493 aa
AGOS_AFR512W,  E.gossypii
AGOS_AFR512W
NP_986059.2
496 aa
dld1,  S.pombe
dld1
NP_593496.1
511 aa
MGG_17072,  M.oryzae
MGG_17072
XP_003716343.1
508 aa
NCU02407,  N.crassa
NCU02407
XP_959535.2
504 aa
mtLPD1,  A.thaliana
mtLPD1
NP_175237.1
507 aa
mtLPD2,  A.thaliana
mtLPD2
NP_566570.3
507 aa
Os01g0328700,  O.sativa
Os01g0328700
NP_001042918.1
503 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Maple syrup urine disease, type III.
Leigh syndrome.



Publications
Articles associated with genes and sequences of this homology group.

A core metabolic enzyme mediates resistance to phosphine gas.
Schlipalius DI, et al. Science 338, 807-10 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NAD_binding_8 (pfam13450)
  NAD(P)-binding Rossmann-like domain.
Pyr_redox (pfam00070)
  Pyridine nucleotide-disulphide oxidoreductase.
Pyr_redox_dim (pfam02852)
  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.
Glycosyltransferase_GTB_type (cl10013)
  Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
Pyr_redox (pfam00070)
  Pyridine nucleotide-disulphide oxidoreductase.
Pyr_redox_dim (pfam02852)
  Pyridine nucleotide-disulphide oxidoreductase, dimerization domain.
Glycosyltransferase_GTB_type (cl10013)
  Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NAD_binding_8 (cl19134)
  NAD(P)-binding Rossmann-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dld includes H.sapiens DLD and R.norvegicus Dld.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 16 species)
Actinopterygii - bony fishes (17 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (59 transcripts, 34 species)
Liliopsida - monocots (22 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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