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HomoloGene:9015. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SARM1,  H.sapiens
sterile alpha and TIR motif containing 1
NP_055892.2
724 aa
SARM1,  P.troglodytes
sterile alpha and TIR motif containing 1
XP_003315585.1
724 aa
SARM1,  M.mulatta
sterile alpha and TIR motif containing 1
XP_001106275.2
724 aa
SARM1,  C.lupus
sterile alpha and TIR motif containing 1
XP_548285.2
724 aa
Sarm1,  M.musculus
sterile alpha and HEAT/Armadillo motif containing 1
NP_001161993.1
764 aa
Sarm1,  R.norvegicus
sterile alpha and TIR motif containing 1
NP_001099287.1
724 aa
SARM1,  G.gallus
sterile alpha and TIR motif containing 1
XP_415814.4
717 aa
sarm1,  X.tropicalis
sterile alpha and TIR motif containing 1
XP_002937189.2
719 aa
sarm1,  D.rerio
sterile alpha and TIR motif containing 1
NP_001124068.1
713 aa
Ect4,  D.melanogaster
Ectoderm-expressed 4
NP_001246663.1
1059 aa
AgaP_AGAP005901,  A.gambiae
AgaP_AGAP005901
XP_315931.4
1032 aa
tir-1,  C.elegans
tir-1
NP_497784.1
930 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Sarm1-mediated axon degeneration requires both SAM and TIR interactions.
Gerdts J, et al. J Neurosci 33, 13569-80 (2013).
T-cell death following immune activation is mediated by mitochondria-localized SARM.
Panneerselvam P, et al. Cell Death Differ 20, 478-89 (2013).
UXT plays dual opposing roles on SARM-induced apoptosis.
Sethurathinam S, et al. FEBS Lett 587, 3296-302 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TIR_2 (pfam13676)
  TIR domain.
ARM (cl02500)
  Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
TIR_2 (cl17458)
  TIR domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sarm1 includes H.sapiens SARM1 and R.norvegicus Sarm1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 10 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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