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HomoloGene:55474. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CR1,  H.sapiens
complement component (3b/4b) receptor 1 (Knops blood group)
2489 aa
CR1,  P.troglodytes
complement component (3b/4b) receptor 1 (Knops blood group)
2039 aa
CR1,  M.mulatta
complement component (3b/4b) receptor 1 (Knops blood group)
1586 aa
LOC102157092,  C.lupus
complement receptor type 1-like
900 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

?SLE susceptibility.
CR1 deficiency.
Blood group, Knops system.
Malaria, severe, resistance to.

Articles associated with genes and sequences of this homology group.

Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Hazrati LN, et al. Neurobiol Aging 33, 2949.e5-2949.e12 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CCP (cl00043)
  SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (3 transcripts, 3 species)




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