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HomoloGene:4539. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

POLE,  H.sapiens
polymerase (DNA directed), epsilon, catalytic subunit
NP_006222.2
2286 aa
POLE,  P.troglodytes
polymerase (DNA directed), epsilon
XP_522564.4
829 aa
POLE,  C.lupus
polymerase (DNA directed), epsilon, catalytic subunit
XP_543348.3
2237 aa
POLE,  B.taurus
polymerase (DNA directed), epsilon, catalytic subunit
NP_001178358.1
2289 aa
Pole,  M.musculus
polymerase (DNA directed), epsilon
NP_035262.2
2283 aa
Pole,  R.norvegicus
polymerase (DNA directed), epsilon, catalytic subunit
NP_001100622.2
2283 aa
POLE,  G.gallus
polymerase (DNA directed), epsilon, catalytic subunit
XP_004934482.1
2309 aa
pole,  X.tropicalis
polymerase (DNA directed), epsilon, catalytic subunit
XP_004910692.1
2286 aa
pole,  D.rerio
polymerase (DNA directed), epsilon
NP_001121995.1
2284 aa
DNApol-epsilon,  D.melanogaster
DNA polymerase epsilon
NP_524462.2
2236 aa
AgaP_AGAP004615,  A.gambiae
AgaP_AGAP004615
XP_315205.4
2219 aa
F33H2.5,  C.elegans
F33H2.5
NP_493616.1
2144 aa
POL2,  S.cerevisiae
POL2
NP_014137.1
2222 aa
KLLA0C02585g,  K.lactis
KLLA0C02585g
XP_452312.1
2185 aa
AGOS_AFR657C,  E.gossypii
AGOS_AFR657C
NP_986205.2
2180 aa
cdc20,  S.pombe
cdc20
NP_596354.1
2199 aa
MGG_03850,  M.oryzae
MGG_03850
XP_003720041.1
2240 aa
NCU04548,  N.crassa
NCU04548
XP_955939.2
2262 aa
TIL2,  A.thaliana
TIL2
NP_180280.2
2138 aa
TIL1,  A.thaliana
TIL1
NP_172303.5
2161 aa
Os02g0511900,  O.sativa
Os02g0511900
NP_001046939.2
2175 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Kinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε.
Zahurancik WJ, et al. Biochemistry 52, 7041-9 (2013).
Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer.
Zhou Q, et al. Cancer Genomics Proteomics 5, 287-92 (2008).
H2B-K123 ubiquitination stimulates RNAPII elongation independent of H3-K4 methylation.
Shukla A & Bhaumik SR. Biochem Biophys Res Commun 359, 214-20 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cornifin (pfam02389)
  Cornifin (SPRR) family.
DUF1744 (pfam08490)
  Domain of unknown function (DUF1744).
COG1933 (COG1933)
  Archaeal DNA polymerase II, large subunit [DNA replication, recombination, and repair]
POLBc (cl10023)
  DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both ...
DNA_pol_B_exo1 (pfam03104)
  DNA polymerase family B, exonuclease domain.
DUF1744 (pfam08490)
  Domain of unknown function (DUF1744).
DnaQ_like_exo (cl10012)
  DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pole includes H.sapiens POLE and R.norvegicus Pole.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (25 transcripts, 13 species)
Liliopsida - monocots (9 transcripts, 5 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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