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HomoloGene:1068. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ECE1,  H.sapiens
endothelin converting enzyme 1
NP_001106820.1
767 aa
ECE1,  P.troglodytes
endothelin converting enzyme 1
XP_001162780.1
770 aa
ECE1,  M.mulatta
endothelin converting enzyme 1
XP_001099089.1
767 aa
ECE1,  C.lupus
endothelin converting enzyme 1
XP_544514.3
814 aa
ECE1,  B.taurus
endothelin converting enzyme 1
NP_851352.1
758 aa
Ece1,  M.musculus
endothelin converting enzyme 1
NP_955011.1
753 aa
Ece1,  R.norvegicus
endothelin converting enzyme 1
NP_446048.2
754 aa
ECE1,  G.gallus
endothelin converting enzyme 1
NP_990048.1
752 aa
ece1,  D.rerio
endothelin converting enzyme 1
NP_001071260.1
752 aa
Nep3,  D.melanogaster
Neprilysin 3
NP_001245776.1
786 aa
AgaP_AGAP007796,  A.gambiae
AgaP_AGAP007796
XP_317711.1
785 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypertension, essential, susceptibility to.
Hirschsprung disease, cardiac defects, and autonomic dysfunction.



Publications
Articles associated with genes and sequences of this homology group.

Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c.
Kuruppu S, et al. Biochem Biophys Res Commun 427, 606-10 (2012).
Endothelin Converting Enzyme-1 phosphorylation and trafficking.
Kuruppu S & Smith AI. FEBS Lett 586, 2212-7 (2012).
Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia.
Palmer JC, et al. Neuropathol Appl Neurobiol 36, 487-97 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ece1 includes H.sapiens ECE1 and R.norvegicus Ece1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (13 transcripts, 10 species)
Mammalia - mammals (11 transcripts, 11 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 7 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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