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HomoloGene:55463. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SHOX,  H.sapiens
short stature homeobox
292 aa
SHOX,  C.lupus
short stature homeobox
291 aa
SHOX,  B.taurus
short stature homeobox
306 aa
SHOX,  G.gallus
short stature homeobox
291 aa
shox,  X.tropicalis
short stature homeobox
334 aa
shox,  D.rerio
short stature homeobox
285 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Leri-Weill dyschondrosteosis.
Langer mesomelic dysplasia.
Short stature, idiopathic familial.

Articles associated with genes and sequences of this homology group.

New roles of SHOX as regulator of target genes.
Rappold GA, et al. Pediatr Endocrinol Rev 9 Suppl 2, 733-8 (2012).
Genotypes and phenotypes of children with SHOX deficiency in France.
Rosilio M, et al. J Clin Endocrinol Metab 97, E1257-65 (2012).
The role of the SHOX gene in the pathophysiology of Turner syndrome.
Oliveira CS & Alves C. Endocrinol Nutr 58, 433-42 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OAR (pfam03826)
  OAR domain.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (6 transcripts, 5 species)
Mammalia - mammals (3 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)




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