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HomoloGene:55463. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SHOX,  H.sapiens
short stature homeobox
NP_000442.1
292 aa
SHOX,  C.lupus
short stature homeobox
NP_001020793.1
291 aa
SHOX,  B.taurus
short stature homeobox
NP_001178475.1
306 aa
SHOX,  G.gallus
short stature homeobox
NP_001073192.1
291 aa
shox,  X.tropicalis
short stature homeobox
XP_004911874.1
334 aa
shox,  D.rerio
short stature homeobox
NP_001119883.1
285 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leri-Weill dyschondrosteosis.
Langer mesomelic dysplasia.
Short stature, idiopathic familial.



Publications
Articles associated with genes and sequences of this homology group.

New roles of SHOX as regulator of target genes.
Rappold GA, et al. Pediatr Endocrinol Rev 9 Suppl 2, 733-8 (2012).
Genotypes and phenotypes of children with SHOX deficiency in France.
Rosilio M, et al. J Clin Endocrinol Metab 97, E1257-65 (2012).
The role of the SHOX gene in the pathophysiology of Turner syndrome.
Oliveira CS & Alves C. Endocrinol Nutr 58, 433-42 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OAR (pfam03826)
  OAR domain.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (6 transcripts, 5 species)
Mammalia - mammals (3 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

 

 

 

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