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HomoloGene:712. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PDHB,  H.sapiens
pyruvate dehydrogenase (lipoamide) beta
NP_000916.2
359 aa
PDHB,  P.troglodytes
pyruvate dehydrogenase (lipoamide) beta
NP_001233347.1
359 aa
PDHB,  M.mulatta
pyruvate dehydrogenase (lipoamide) beta
XP_001096445.1
359 aa
PDHB,  C.lupus
pyruvate dehydrogenase (lipoamide) beta
XP_533778.2
359 aa
PDHB,  B.taurus
pyruvate dehydrogenase (lipoamide) beta
NP_001030512.2
359 aa
Pdhb,  M.musculus
pyruvate dehydrogenase (lipoamide) beta
NP_077183.1
359 aa
Pdhb,  R.norvegicus
pyruvate dehydrogenase (lipoamide) beta
NP_001007621.1
359 aa
PDHB,  G.gallus
pyruvate dehydrogenase (lipoamide) beta
NP_001185549.1
359 aa
pdhb,  X.tropicalis
pyruvate dehydrogenase (lipoamide) beta
NP_001016212.1
360 aa
pdhb,  D.rerio
pyruvate dehydrogenase (lipoamide) beta
NP_998319.1
359 aa
CG11876,  D.melanogaster
CG11876
NP_651668.1
365 aa
AgaP_AGAP010421,  A.gambiae
AgaP_AGAP010421
XP_311527.2
355 aa
pdhb-1,  C.elegans
pdhb-1
NP_500340.1
352 aa
PDB1,  S.cerevisiae
PDB1
NP_009780.1
366 aa
KLLA0F09603g,  K.lactis
KLLA0F09603g
XP_455516.1
354 aa
AGOS_AAR167C,  E.gossypii
AGOS_AAR167C
NP_982710.1
359 aa
pdb1,  S.pombe
pdb1
NP_596272.1
366 aa
MGG_10569,  M.oryzae
MGG_10569
XP_003721383.1
383 aa
NCU03004,  N.crassa
NCU03004
XP_965390.1
379 aa
MAB1,  A.thaliana
MAB1
NP_199898.1
363 aa
Os09g0509200,  O.sativa
Os09g0509200
NP_001063627.1
376 aa
Os08g0536000,  O.sativa
Os08g0536000
NP_001062360.1
374 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pyruvate dehydrogenase E1-beta deficiency.



Publications
Articles associated with genes and sequences of this homology group.

PDH E1β deficiency with novel mutations in two patients with Leigh syndrome.
Quintana E, et al. J Inherit Metab Dis 32 Suppl 1, S339-43 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Transketolase_C (pfam02780)
  Transketolase, C-terminal domain.
Transketolase_C (pfam02780)
  Transketolase, C-terminal domain.
TPP_enzyme_PYR (cl11410)
  Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pdhb includes H.sapiens PDHB and R.norvegicus Pdhb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 17 species)
Actinopterygii - bony fishes (16 transcripts, 11 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (26 transcripts, 13 species)
Arachnida - arachnids (2 transcripts, 2 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (59 transcripts, 32 species)
Liliopsida - monocots (22 transcripts, 9 species)
Coniferopsida - conifers (6 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (7 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (8 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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