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HomoloGene:55843. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

LATS1,  H.sapiens
large tumor suppressor kinase 1
1130 aa
LATS1,  P.troglodytes
LATS, large tumor suppressor, homolog 1 (Drosophila)
1130 aa
LOC696131,  M.mulatta
serine/threonine-protein kinase LATS1-like
1130 aa
LATS1,  B.taurus
LATS, large tumor suppressor, homolog 1 (Drosophila)
1123 aa
Lats1,  M.musculus
large tumor suppressor
1129 aa
Lats1,  R.norvegicus
large tumor suppressor kinase 1
1130 aa
LATS1,  G.gallus
LATS, large tumor suppressor, homolog 1 (Drosophila)
1136 aa
lats1,  X.tropicalis
large tumor suppressor kinase 1
983 aa
lats1,  D.rerio
LATS, large tumor suppressor, homolog 1 (Drosophila)
1068 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
UBA (pfam00627)
  UBA/TS-N domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lats1 includes H.sapiens LATS1 and R.norvegicus RGD1564085.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 9 species)
Actinopterygii - bony fishes (4 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (4 transcripts, 4 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Gastropoda - gastropods (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)




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