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HomoloGene:259. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

POU1F1,  H.sapiens
POU class 1 homeobox 1
317 aa
POU1F1,  P.troglodytes
POU class 1 homeobox 1
317 aa
POU1F1,  M.mulatta
POU class 1 homeobox 1
317 aa
POU1F1,  C.lupus
POU class 1 homeobox 1
291 aa
POU1F1,  B.taurus
POU class 1 homeobox 1
291 aa
Pou1f1,  M.musculus
POU domain, class 1, transcription factor 1
291 aa
Pou1f1,  R.norvegicus
POU class 1 homeobox 1
291 aa
POU1F1,  G.gallus
POU class 1 homeobox 1
327 aa
pou1f1,  X.tropicalis
POU class 1 homeobox 1
323 aa
pou1f1,  D.rerio
POU domain, class 1, transcription factor 1
350 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Pituitary hormone deficiency, combined.

Articles associated with genes and sequences of this homology group.

Polymorphisms of Pit-1 gene and its association with growth traits in chicken.
Bhattacharya TK, et al. Poult Sci 91, 1057-64 (2012).
Pit-1 mutation and lipoedema in a family.
Bano G, et al. Exp Clin Endocrinol Diabetes 118, 377-80 (2010).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pou (cl02582)
  Pou domain - N-terminal to homeobox domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pou1f1 includes H.sapiens POU1F1 and R.norvegicus Pou1f1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)




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