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HomoloGene:75001. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCN2A,  H.sapiens
sodium channel, voltage-gated, type II, alpha subunit
NP_001035233.1
2005 aa
SCN2A,  P.troglodytes
sodium channel, voltage-gated, type II, alpha subunit
XP_001153227.1
2005 aa
SCN2A,  M.mulatta
sodium channel, voltage-gated, type II, alpha subunit
XP_001099916.1
2017 aa
SCN2A,  C.lupus
sodium channel, voltage-gated, type II, alpha subunit
XP_535939.2
2006 aa
SCN2A,  B.taurus
sodium channel, voltage-gated, type II, alpha subunit
NP_001137581.1
2006 aa
Scn2a1,  M.musculus
sodium channel, voltage-gated, type II, alpha 1
NP_001092768.1
2006 aa
Scn2a1,  R.norvegicus
sodium channel, voltage-gated, type II, alpha 1
NP_036779.1
2005 aa
SCN2A,  G.gallus
sodium channel, voltage-gated, type II, alpha subunit
XP_004942844.1
2017 aa
scn3a,  X.tropicalis
sodium channel, voltage-gated, type III, alpha subunit
XP_002939317.2
2008 aa
scn1lab,  D.rerio
sodium channel, voltage-gated, type I like, alpha b
NP_001038360.1
1996 aa
para,  D.melanogaster
paralytic
NP_001188624.1
2084 aa
AgaP_AGAP004707,  A.gambiae
AgaP_AGAP004707
XP_554647.3
2092 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Seizures, afebrile.
Seizures, benign familial neonatal-infantile.



Publications
Articles associated with genes and sequences of this homology group.

Clinical spectrum of SCN2A mutations expanding to Ohtahara syndrome.
Nakamura K, et al. Neurology 81, 992-8 (2013).
Compromised function in the Na(v)1.2 Dravet syndrome mutation R1312T.
Lossin C, et al. Neurobiol Dis 47, 378-84 (2012).
Acute encephalopathy with a novel point mutation in the SCN2A gene.
Kobayashi K, et al. Epilepsy Res 102, 109-12 (2012).
Palmitoylation influences the function and pharmacology of sodium channels.
Bosmans F, et al. Proc Natl Acad Sci U S A 108, 20213-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IQ (cl15479)
  IQ calmodulin-binding motif.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn2a1 includes H.sapiens SCN2A1 and R.norvegicus Scn2a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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