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HomoloGene:37347. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

CYP11A1,  H.sapiens
cytochrome P450, family 11, subfamily A, polypeptide 1
NP_000772.2
521 aa
CYP11A1,  P.troglodytes
cytochrome P450, family 11, subfamily A, polypeptide 1
XP_001164690.3
373 aa
CYP11A1,  C.lupus
cytochrome P450, family 11, subfamily A, polypeptide 1
XP_535539.2
520 aa
CYP11A1,  B.taurus
cytochrome P450, family 11, subfamily A, polypeptide 1
NP_788817.1
520 aa
Cyp11a1,  M.musculus
cytochrome P450, family 11, subfamily a, polypeptide 1
NP_062753.3
526 aa
Cyp11a1,  R.norvegicus
cytochrome P450, family 11, subfamily a, polypeptide 1
NP_058982.1
526 aa
CYP11A1,  G.gallus
cytochrome P450, family 11, subfamily A, polypeptide 1
NP_001001756.1
508 aa
LOC100495360,  X.tropicalis
cholesterol side-chain cleavage enzyme, mitochondrial-like
XP_002934608.1
504 aa
LOC563363,  D.rerio
cholesterol side-chain cleavage enzyme, mitochondrial-like
XP_691817.1
512 aa
cyp11a1,  D.rerio
cytochrome P450, subfamily XIA, polypeptide 1
NP_694485.2
509 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adrenal insufficiency, congenital with or without 46, XY sex reversal.
Lipoid congenital adrenal hyperplasia.



Publications
Articles associated with genes and sequences of this homology group.

Differential regulation of the human CYP11A1 promoter in mouse brain and adrenals.
Chiang YF, et al. J Cell Physiol 226, 1998-2005 (2011).
Regulation of steroid production: analysis of Cyp11a1 promoter.
Shih MC, et al. Mol Cell Endocrinol 336, 80-4 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
p450 (pfam00067)
  Cytochrome P450.
p450 (cl12078)
  Cytochrome P450.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cyp11a1 includes H.sapiens CYP11A1 and R.norvegicus Cyp11a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)

 

 

 

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